Introduction Galanin-(2–13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide (M871) is a novel peptide antagonist selectively recognizing the galanin receptor type 2. Galanin (GAL) and its three receptors have bee
Introduction Pep2m, a peptide inhibitor of GluA2 subunit binding to NSF, reduces α-amino- 3-hydroxy-5-methyl-isoxazolepropionate (AMPA) currents.Pharmacologic actionBy infusion into cultured hippocamp
Introduction PMX-53, a chemically synthesized peptide material, is a potent C5a antagonist in human neutrophils and macrophages in vitro, aiming to protect rodents from a number of experimental inflam
Introduction Acid-sensitive ion channels (ASICs) are a class of proton-gated ion channels belonging to the Degenerin/Epithelial sodium channel family (Deg/ENaC) with four encoded genes: ASIC1, ASIC2,
Introduction The serine/threonine kinase Pim-1 plays an important role in cell cycle progression and apoptosis inhibition, resulting in prostate tumorigenesis. Therefore, Pim-1 inhibition has been exp
Introduction ClC-2 chloride channels are voltage-gated ion channels that are expressed in neuronal and epithelial cells where they are critical mediators for the passive diffusion of Cl across the pl
Introduction Guangxitoxin 1E is a KV2.1 and KV2.2 specific channel blocker (IC50 values are 1-3 nM). The experimental results showed that it enhances glucose-stimulated insulin secretion from human is
Introduction The sodium channel subtypes NaV1.2 and NaV1.6 are the two major forms of excitatory pyramidal neurons in the cerebral cortex, with local specificity that can be combined with the initiati
Introduction The peptide st-Ht31 P, A-kinase anchoring protein (AKAP) inhibitor, has the negative control for st-Ht31. In DRG sensory neurons, the st-Ht31 P attenuated forskolin-stimulated translocati
Introduction Orexin A (OXA) and orexin B (OXB) are hypothalamic neuropeptides discovered in 1998, which bind to two G-protein coupled receptors (GPCRs), namely orexin receptor 1 (OX1) and orexin recep
Introduction The voltage-gated Kv1.3 channel in effector memory T cells serves as a new therapeutic target for multiple sclerosis. The molecular weight of ADWX-1 is 4072.8 Da and the ADWX-1 peptide bl
Introduction Tandem P-domain weak inward rectifying K+ (TWIK)-related K+ channel 1 (TREK-1) and TWIK-related acid-sensitive K+ channel 3 (TASK-3) have been proposed to be related to depression. TREK-1
Introduction In the respiratory tract, there are tachykinin P (SP) and neurokinin A (NKA) in capsaicin-sensitive primary afferent neurons. Bradykinin has various effects such as bronchoconstriction, m
Introduction ICl 154,129 is a new compound that shows selectivity as an antagonist of [Leu5]enkephalin and [D-AIa2, D-Leu5]enkephalin at opiate receptors in the mouse vas deferens preparation. The rec
Introduction Nociceptin/orphanin FQ (N/OFQ) modulates various biological functions, including nociception, via selective stimulation of the N/OFQ peptide receptor (NOP). UFP-101 is a novel NOP ligand
What is Trofinetide?
Trofinetide is a neuropeptide synthesized from the breakdown product of insulin-like growth factor 1 (IGF-1). Trofinetide is primarily used to treat Rett syndrome (
Development of Trofinetide
Trofinetide was found in 2002 by Brimble's team at the University of Auckland in New Zealand, while researching a candidate molecule for traumatic brain i
