* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).
Our global business capability is designed to provide you with the highest quality locked nucleic acid oligonucleotides prepared according to your exact specifications. With many years of oligonucleotide synthesis expertise, Creative Peptides is proud of our cooperation with you from early research to commercial launch.
Locked nucleic acid is a kind of RNA analogues based on non-deoxyribose, in which the 2'-O on the ribosome ring is connected to 4'-C, so that the five-membered ring is "locked" in the ideal Watson-Crick three-dimensional binding conformation. Therefore, Locked nucleic acid obeys stronger base complementary pairing, greater base accumulation force and better hybrid stability, and will not be recognized and degraded by nuclease in tissue cells. When a locked nucleic acid monomer is added to the nucleic acid chain, the temperature (TM) value of the double-stranded hybrid can be increased by 2-8℃. Locked nucleic acid increases the differentiation of base mismatch, which can distinguish the difference of single base, and can make the oligos containing locked nucleic acid maintain a high TM value at a shorter length.
References
Creative Peptides has accumulated a huge library of peptide knowledge including frontier peptide articles, application of peptides, useful tools, and more!
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