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Cross-linking refers to the process of chemically bonding two or more molecules through a covalent bond. The crosslinker comprises a reactive end which is reactive with specific functional groups located on proteins or other molecules, such as primary amines and sulfhydryl groups. Multiple chemical groups on proteins and polypeptides can be used for cross-linking, so proteins and polypeptides can be used as targets for coupling in studies using cross-linking methods.
Cross-linkers are used to determine the relationship between adjacent proteins as well as ligand-receptor interactions. Photo-reactive crosslinkers are widely used for nonspecific bioconjugation. While numerous options exist, the two most common photo-reactive chemical groups are diazirines and aryl-azides. Photo cross linkers are used for the study of protein-protein or protein-oligonucleotide interactions in living cells. They are typically used in the following manner:
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References
Creative Peptides has accumulated a huge library of peptide knowledge including frontier peptide articles, application of peptides, useful tools, and more!
Peptide YY is referred to as PYY. Its structure is highly homologous with pancreatic polypeptide (PP) and neurop ...
Lecirelin, a synthetic hormone, is a strongly basic nonapeptide with sequence yr-His-Trp-Ser-Tyr-tBu-D-Gly-Leu-A ...
Figure 1. Chemical structure of pentagastrinPentagastrin, known as peptavlon, is a synthetic pentapeptide that p ...
The serine/threonine kinase Pim-1 plays an important role in cell cycle progression and apoptosis inhibition, re ...
Antioxidant effect of peptides Peptides have been isolated from the resultant by-products in the past 15 years and suggested ...