Peptide modification for Daily Chemical Products
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With the development of biochemical technology, peptide and peptide modification are more and more widely used in the field of daily chemical products. By changing the physicochemical properties of peptide compounds, peptide modification technology can optimize their effective use in the body and improve their application effect in cosmetics and skin care products. This article will discuss the application of peptide modification in improving skin permeability, reducing skin sensitivity, and improving anti-aging and moisturizing effects, and provide corresponding examples.
Palmitic modification enhances skin penetration
The presence of a skin barrier limits the ability of many active ingredients to penetrate into the skin. To overcome this challenge, researchers have extensively explored peptide modification strategies, especially the application of lipophilic modifications such as palmitoylation. Palmitoyl Pentapeptide-4 is a common anti-aging ingredient that successfully enhances its permeability and biological activity in the skin by introducing a palmitoyl group at its C-terminus. This boosting action helps boost collagen synthesis, which significantly reduces the appearance of wrinkles and fine lines. In addition, the researchers also used β-alanine-histidine (carnosine) as a model, and after palmitoylation, it was observed that its permeability in the skin layer was significantly improved. This study reveals that palmitoylation modification is an effective means to not only improve the skin permeability of peptide active ingredients, but also help to enhance their biological effects in the skin. As a result, these findings provide a new scientific basis for the development of more effective skincare products and treatments, and are expected to drive advancements and innovations in skincare technology to meet people's quest for healthier skin.
Table 1. Peptide modification service at Creative Peptides
Alkyl ester modification reduces skin sensitivity
The modification of peptides not only enhances their effectiveness in skin care products, but also significantly reduces their irritation to the skin, making it more suitable for sensitive skin. Researchers have applied the dipeptide Tyr-Arg to topical products and observed a significant reduction in the stinging sensation in the user. The results of this study show that the potential irritation of skin care products can be effectively reduced through specific peptide modifications, thereby improving the comfort of the user experience. Further studies revealed that the application of Tyr-Arg peptide modified with N-acetyl-try-arginine cetyl ester on the skin of volunteers significantly reduced the sensitivity of the skin to heat stimuli. This shows that the modified peptides can not only reduce the discomfort that cosmetics may cause during use, but also help to protect and balance the physiological state of sensitive skin. Therefore, the application of peptide modification in the development of skin care products is not only limited to improving the efficacy of active ingredients, but also improving product tolerance by reducing irritation, which is expected to further promote the innovation and development of skin care technology.
Acylation modification enhances anti-aging benefits
Peptide modification plays a key role in the field of anti-aging skincare. This specific modification can significantly enhance the stability and activity of the peptide, allowing it to exert its anti-aging benefits more effectively. Acetyl hexapeptide-8, also known as botulinoid toxin, is an acetylated hexapeptide. Its mechanism mimics botulinum toxin, which inhibits the release of neurotransmitters, thereby relaxing facial muscles and reducing the formation of dynamic wrinkles. In addition, Palmitoyl Tripeptide-5 can enhance the skin's ability to absorb and retain moisture by binding to lipophilic groups, thereby significantly improving the skin's moisturizing effect. This modification allows the tripeptide to penetrate the skin barrier more effectively, providing the cells with the moisture support they need, which in turn increases the skin's smoothness and elasticity. Advancements in these technologies have not only improved the performance and reliability of skincare products, but also provided consumers with a wider range of options to meet different skin needs and anti-aging goals.
Lipophilic group modification enhances the moisturizing effect
Peptide modification not only plays an important role in anti-aging skin care products, but can also be used to enhance the efficacy of moisturizing products. By combining with humectants, peptide modifications can significantly improve the skin's hydration. For example, Palmitoyl Tripeptide-5 enhances the skin's ability to absorb and retain moisture when combined with lipophilic groups. This modification not only allows the tripeptide to penetrate the skin barrier more effectively, but also provides the cells with the moisture support they need, thereby improving the skin's hydration effect.
Modified peptides with higher security
The safety of cosmetics has always been the focus of the industry. The modified peptide exhibits a high safety profile during application. The United States Cosmetic Ingredient Evaluation Committee (CIR) has announced the safety of most oligopeptides used in cosmetics, such as tripeptide-1, hexapeptide-12, and the salts and fatty acyl derivatives of the above two, palmitoyl tetrapeptide-7 and other peptides. These ingredients are reported to be used primarily as multifunctional skin conditioning agents in cosmetics, with no data on genotoxicity, skin irritation and sensitization, carcinogenicity, or reproductive and developmental toxicity found.
Table 2. Cosmetic Peptides at Creative Peptides
Summary
Peptide modification technology has a wide range of application prospects in cosmetics and skin care products. Through specific modifications, the skin penetration of the active ingredient can be significantly improved, the irritation of the product can be reduced, and the anti-aging and moisturizing effects can be enhanced. In the future, with the continuous progress of technology, peptide modification will play a greater role in daily chemical products to meet consumers' needs for efficient, safe, and innovative products.
References
- Lintner, and Peschard. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. International journal of cosmetic science 22.3 (2000): 207-218.
- Johnson Jr, Wilbur, et al., Safety assessment of tripeptide-1, hexapeptide-12, their metal salts and fatty acyl derivatives, and palmitoyl tetrapeptide-7 as used in cosmetics. International journal of toxicology 37.3_suppl (2018): 90S-102S.
- Babizhayev, Mark A., et al., Biologic Activities of Molecular Chaperones and Pharmacologic Chaperone Imidazole-Containing Dipeptide-Based Compounds: Natural Skin Care Help and the Ultimate Challenge. Implication for Adaptive Responses in the Skin. American Journal of Therapeutics 19.2 (2012): e69-e89.
- Zhao, Xiaocao, et al., Collagen peptides and the related synthetic peptides: A review on improving skin health. Journal of Functional Foods 86 (2021): 104680.
- Skibska, Agnieszka, and Renata Perlikowska. Signal peptides-promising ingredients in cosmetics. Current Protein and Peptide Science 22.10 (2021): 716-728.
