Bestatin hydrochloride

Bestatin hydrochloride is a reversible inhibitor of aminopeptidase enzymes, namely Aminopeptidase B, Aminopeptidase M (CD13), and leucine aminopeptidase (LAP3). Inhibition of these proteins by bestatin correlates to apoptosis induction in oncogenic cells. Bestatin is also a potent inhibitor of leukotriene A4 hydrolase (LTA4). It is potentially used for cancer treatment.

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CAT#	R1028
CAS	65391-42-6
Synonyms/Alias	Aminopeptidase inhibitor; leucine aminopeptidase; aminopeptidase B; NK-421
M.F/Formula	C16H24N2O4 · HCl
M.W/Mr.	344.83
Labeling Target	Aminopeptidase
Appearance	White solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Activity	Inhibitor

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Storage	-20°C
Solubility	Soluble in DMSO
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions	Dry, dark and at 0 - 4 °C
Long-term Storage Conditions	-20 °C
InChI	InChI=1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
InChI Key	XGDFITZJGKUSDK-UDYGKFQRSA-N
Isomeric SMILES	CC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](CC1=CC=CC=C1)N)O.Cl
BoilingPoint	604.7ºC at 760 mmHg
ShelfLife	>2 years if stored properly
Melting Point	216-218 °C