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Thymopentin Acetate

Thymopentin, also known as TP-5, is a synthetic derivative of thymopoietin, a thymic hormone, and has immunoregulatory properties. Thymopentin interacts with T cells, reduces endocrine and behavioral responses to experimental stress. It is also found to increase the number of cells undergoing apoptosis in irradiated cells and selectively bind to apoptotic cells.

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CAT No: 10-101-33

CAS No: 69558-55-0 (net)

Synonyms/Alias: Thymopentin monoacetate; Thymopentin Acetate; 177966-81-3; 89318-88-7; Thymopentin (acetate); UNII-1938Y8P51M; DTXSID80237615; Thymopentin acetate salt H-Arg-Lys-Asp-Val-Tyr-OH acetate salt; 1938Y8P51M; L-Tyrosine, L-arginyl-L-lysyl-L-alpha-aspartyl-L-valyl-, monoacetate (Salt); L-Tyrosine, N-(N-(N-(n2-L-arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)-, monoacetate; acetic acid;(3S)-3-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid; Thymopentin acetate salt; MFCD00133107; SCHEMBL270731; HY-N7122A; DTXCID30160106; FT109621; MS-31284; H-Arg-Lys-Asp-Val-Tyr-OH; H-RKDVY-OH; CS-0113786; G12349; Q27252059; Thymopentin acetate (H-L-Arg-L-Lys-L-Asp-L-Val-L-Tyr-OH.Ac); L-TYROSINE, L-ARGINYL-L-LYSYL-L-.ALPHA.-ASPARTYL-L-VALYL-, MONOACETATE (SALT); L-TYROSINE, N-(N-(N-(N2-L-ARGINYL-L-LYSYL)-L-.ALPHA.-ASPARTYL)-L-VALYL)-, MONOACETATE

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Specification Technical Data Publications Customer reviews and Q&A
M.F/FormulaC32H53N9O11
M.W/Mr.739.8
SequenceOne Letter Code:RKDVY
Three Letter Code:H-Arg-Lys-Asp-Val-Tyr-OH.CH3CO2H
ApplicationThymopentin is an immunostimulant. It had been used in several clinical studies in the early years of the AIDS pandemic (from 1983 to 1985).
Areas of InterestImmunomodulating Agents
Source#Synthetic
Solubility−20°C
InChIInChI=1S/C30H49N9O9.C2H4O2/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34;1-2(3)4/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35);1H3,(H,3,4)/t19-,20-,21-,22-,24-;/m0./s1
InChI KeyYRTISBKUCLDRGF-ADVSENJOSA-N
BoilingPointN/A
References

Human immature thymocytes express significant levels of the CD10 (endopeptidase 24.11) cell surface antigen. We report here that IOB5, an anti-CD10 mAb, as well as the phorbol ester PMA down-regulate CD10 activity at the surface of human thymocytes. The kinetics of CD10 modulation were drastically different for both effectors, indicating different regulatory mechanisms. We also demonstrated that intact human thymocytes hydrolyze thymopentin and that CD10 significantly participates in this process. Finally, we found that thymopentin and to a lesser extent phosphoramidon, a specific endopeptidase 24.11 inhibitor, induced up-regulation of CD4 and CD8 molecules at the thymocyte cell surface. In view of these results, we suggest that down-regulation of endopeptidase 24.11 at the thymocyte cell surface might reduce its activity toward thymic factors possibly involved in the regulation of thymocyte functions.

Guerin, S., Mari, B., Belhacene, N., Rossi, B., Peyron, J. F., & Auberger, P. (1997). CD10 (endopeptidase 24.11) is a thymic peptide-degrading enzyme possibly involved in the regulation of thymocyte functions. Cellular immunology, 175(1), 85-91.

Melting PointN/A

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