Deslorelin

Deslorelin

Deslorelin is a gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and oestrogen). It is currently approved for use in veterinary medicine and is used to induce ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland.

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CAT No: R1948

CAS No: 57773-65-6

Synonyms/Alias: Deslorelin;57773-65-6;Deslorelina;Desloreline;Somagard;D-Trp LHRH-PEA;Deslorelinum;D-Trp-LHRH-PEA;Bachem 9022;UNII-TKG3I66TVE;TKG3I66TVE;GNRH (D-Trp6,pro9-net);(D-Trp6,Pro9-NHEt)LH-RH;Desloreline [INN-French];Deslorelinum [INN-Latin];Deslorelina [INN-Spanish];(D-Trp6,des-Gly10)-LH-RH ethylamide;(de-Gly10,D-Trp6,Pro-NHEt)-LH-RH;(Des-Gly10(D-Tro6)-LH-RH ethylamide;(D-Trp(sub 6)-pro(sup 9)-NEt)-GNRH;(D-Trp6,des-Gly-NH210)-LH-RH ethylamide;DTXSID2048323;D-Trp(sup 6)-pro(sup 9)-N-ethylamide-LHRH;(D-Trp(sup 6)-pro(sup 9))-LHRH ethylamide;H 4065;Des-Gly-10-Trp-6-ethylamide-LHRH;GnRH, Trp(6)-N-Et-ProNH2(9)-;LHRH, Trp(6)-N-Et-ProNH2(9)-;GnRH, des-Gly(10)-Trp(6)-ethylamide-;LHRH, des-Gly(10)-Trp(6)-ethylamide-;6-Trp-9-N-Et-Pro-10-des-GlyNH2-LHRH;Desloreline (INN-French);Deslorelinum (INN-Latin);Deslorelina (INN-Spanish);DESLORELIN (MART.);DESLORELIN [MART.];LHRH, des-glycyl(10)-tryptophyl(6)-ethylamide-;5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide;(D-TRP(SUP 6),DES-GLY(SUP 10))-LH-RH ETHYLAMIDE;LHRH, tryptophyl(6)-N-ethylprolinamide(9)-des-glycinamide(10)-;NCGC00167516-01;Deslorelin [USAN:INN:BAN];Deslorelin?;Deslorellin acetate;LHRH-T;DESLORELIN [MI];DESLORELIN [INN];Deslorelin (USAN/INN);DESLORELIN [USAN];DESLORELIN [WHO-DD];SCHEMBL59413;GTPL9343;CHEMBL2365665;DTXCID0028298;SCHEMBL19409316;BDBM84726;CHEBI:177570;GJKXGJCSJWBJEZ-XRSSZCMZSA-N;MFCD00167401;AKOS015994649;AC-8917;CS-5746;DB11510;HS-2009;NCGC00167516-02;NCGC00167516-03;HY-12556;6-D-phenylalanine-9-(N-ethyl-L-prolinamide)-;D03694;G78019;Q5264591;[des-Gly10, D-Trp6]-LH-RH ethylamide, >=97% (HPLC);6-D-Tryptophan-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (swine);Bachem 9022;D-Trp LHRH-PEA;

Chemical Name: (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

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M.F/Formula	C64H83N17O12
M.W/Mr.	1282.4
Sequence	One Letter Code:XHWSYWLRP Three Letter Code:H-Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt
Appearance	Solid powder

Long-term Storage Conditions	Soluble in DMSO, not in water
InChI	InChI=1S/C64H83N17O12/c1-4-68-62(92)53-16-10-24-81(53)63(93)46(15-9-23-69-64(65)66)74-56(86)47(25-35(2)3)75-58(88)49(27-37-30-70-43-13-7-5-11-41(37)43)77-57(87)48(26-36-17-19-40(83)20-18-36)76-61(91)52(33-82)80-59(89)50(28-38-31-71-44-14-8-6-12-42(38)44)78-60(90)51(29-39-32-67-34-72-39)79-55(85)45-21-22-54(84)73-45/h5-8,11-14,17-20,30-32,34-35,45-53,70-71,82-83H,4,9-10,15-16,21-29,33H2,1-3H3,(H,67,72)(H,68,92)(H,73,84)(H,74,86)(H,75,88)(H,76,91)(H,77,87)(H,78,90)(H,79,85)(H,80,89)(H4,65,66,69)/t45-,46-,47-,48-,49+,50-,51-,52-,53-/m0/s1
InChI Key	GJKXGJCSJWBJEZ-XRSSZCMZSA-N
Canonical SMILES	CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8
Isomeric SMILES	CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8

1. cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging

2. Store-operated Ca2+ entry sustains the fertilization Ca2+ signal in pig eggs

3. Constitutive and inflammation-dependent antimicrobial peptides produced by epithelium are differentially processed and inactivated by the commensal Finegoldia magna and the pathogen Streptococcus pyogenes

4. Implications of ligand-receptor binding kinetics on GLP-1R signalling

5. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate

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