Glucagon

Glucagon

Glucagon (Porcine glucagon) is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis. Glucagon decreases the activity of HNF-4. Glucagon increases HNF4α phosphorylation.

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CAT No: 10-101-18

CAS No: 16941-32-5

Synonyms/Alias: GLUCAGON;16941-32-5;Glucagonum;Glucagon (swine);Glucagone;9007-92-5;Bovine glucagon;Glukagon Novo;Glucagon, pig;Glucagon (dog);Glucagon (ox);Big plasma glucagon;Glucagon HCl;Glucagon (Xenopus laevis);Glucagon (Saimiri sciureus);UNII-76LA80IG2G;Glucagon (Mesocricetus auratus);Glucagon, porcine, for bioassay;Glukagon;Gut glucagon-like immunoreactants;HSDB 3337;DTXSID101016809;Glucagon, porcine, for immunoassay;HSQGTFTSDYSKYLDSRRAQDFVQWLMNT;EINECS 232-708-2;Glucagonum (INN-Latin);Glucagonum [INN-Latin];HG-Factor;His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr;Glucagon (USP:INN:BAN:JAN);Glucagon [USP:INN:BAN:JAN];Hyperglycemic-Glycogenolytic Factor;HG Factor;His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr;Glucagon (1-29);Proglucagon (33-61);Glucagon-like-immunoreactivity;Gvoke KitVial;Gvoke Kit;Glucagon (pig);Glucagon, porcine;Gvoke PFS;Glucagone [DCIT];Glucagon1555;BAQSIMI;GVOKE HYPOPEN;GLUCAGON (MART.);glucagon injection, solution;76LA80IG2G;GLUCAGON (USP IMPURITY);GLUCAGON (USP MONOGRAPH);SCHEMBL15268863;Gvoke HypoPen1 mg Auto-Injector;H04AA01;DTXCID701475001;Gvoke PFS1 mg Pre-filled Syringe;Gvoke HypoPen0.5 mg Auto-Injector;Gvoke PFS0.5 mg Pre-filled Syringe;AKOS040741791;NCGC00167140-01;Glucagon (1-29), bovine, human, porcine;Glucagon, acetate salt, >=97.0% (HPLC);NS00078784;F85453;Human glucagon, European Pharmacopoeia (EP) Reference Standard;232-708-2;HIS-SER-GLU(NH2)-GLY-THR-PHE-THR-SER-ASP-TYR-SER-LYS-TY R-LEU-ASP-SER-ARG-ARG-ALA-GLU(NH2)-ASP-PHE-VAL-GLU(NH2)-TRP-LEU-MET-ASP(NH2)-THR;L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine;L-Threonine, L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-.alpha.-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-.alpha.-aspartyl-L-seryl-L-arginyl-L-argin yl-L-alanyl-L-glutaminyl-L-.alpha.-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-;L-Threonine, L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glytaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-;

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M.F/Formula	C153H225N43O49S
M.W/Mr.	3482.7
Sequence	One Letter Code:HSQGTFTSDYSKYLDSRRAQDFVQWLMNT Three Letter Code:H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH

Long-term Storage Conditions	DMSO : 50 mg/mL (14.36 mM; Need ultrasonic)
Shipping Condition	Room temperature in continental US; may vary elsewhere.
InChI	InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
InChI Key	MASNOZXLGMXCHN-ZLPAWPGGSA-N

1. Proinsulin C-peptide and insulin: Limited pattern similarities of interest in inter-peptide interactions but no C-peptide effect on insulin and IGF-1 receptor signaling

2. Myotropic activity and immunolocalization of selected neuropeptides of the burying beetle Nicrophorus vespilloides (Coleoptera: Silphidae)

3. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis

4. Uncarboxylated osteocalcin decreases insulin-stimulated glucose uptake without affecting insulin signaling and regulators of mitochondrial biogenesis in myotubes

5. TMEM16F and dynamins control expansive plasma membrane reservoirs

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