SHLP1 (Small humanin-like peptide 1)
SHLP1 (Small humanin-like peptide 1)
Recent advances in high-resolution sequencing have led to the discovery of unique peptides derived from mitochondrial genome.1-2 Currently 8 peptides are identified: humanin, mitochondrial open reading frame of the 12S tRNA-c (MOTS-c), and six small humanin-like peptides (SHLP1-6). 1-2 All of these peptides are released into cytosol from mitochondria and associate with increased longevity and cell viability, reduced apoptosis, and other beneficial functions. 1-3 MOTS-c was found to reduce insulin resistance, decrease obesity, and promote homeostasis. 3
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| CAT# | X21189 |
| M.W/Mr. | 2393.6 |
| Sequence | One Letter Code: H-MCHWAGGASNTGDARGDVFGKQAG-OH
Three Letter Code: NH2-Met-Cys-His-Trp-Ala-Gly-Gly-Ala-Ser-Asn-Thr-Gly-Asp-Ala-Arg-Gly-Asp-Val-Phe-Gly-Lys-Gln-Ala-Gly-COOH |
| Storage | -20°C |
References | 1. Cobb L. J. et al., AGING 8 (4), 796-808 (2016).
2. Okada A. K. et al., Sci Reports 7 (7802), 1-10 (2017).
3. Lee C., et al., Cell Met 21, 443-454 (2015). |
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