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DAPTA

DAPTA, an analog of peptide T, acts as a chemokine receptor 5 (CCR5) antagonist that inhibits the entry of the virus. It is used potentially for the treatment of HIV infection and HBV infection.

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CAT No: R1013

CAS No: 106362-34-9

Synonyms/Alias: DAPTA;106362-34-9;Adaptavir;(D-Ala1)-peptide T amide;D-Ala-peptide T-amide;RAP101;L-Threoninamide, D-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-;CHEMBL181276;J208V4ZMP2;(2S)-N-[(2S)-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2R)-2-aminopropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]butanediamide;D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH2;(S)-2-((2S,5S,8S,11S,14R)-14-Amino-2,5,8-tris((R)-1-hydroxyethyl)-11-(hydroxymethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecanamido)-N1-((S)-1-(((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)succinamide;mDAPTA;monomeric D-Ala-peptide;D-Ala1-peptide T-amide;UNII-J208V4ZMP2;(D-Alanine1)Peptide T amide;Monomeric DAPTA;MFCD00076838;D-Ala1-peptide T-NH2;H-D-ALA-SER-THR-THR-THR-ASN-TYR-THR-NH2;[D-Ala1] Peptide T Amide;SCHEMBL7706935;monomeric d-Ala-peptide T-amide;GTPL11692;HY-P1034;PEPTIDE T AMIDE, 1(D-ALA);BDBM50607887;s8501;AKOS024457091;CCG-270535;CS-7601;NCGC00599627-01;AC-31499;AS-58148;DA-59547;FA109659;D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH(2);A11871;BRD-K37151368-001-01-7;Q27281035;

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M.F/FormulaC35H56N10O15
M.W/Mr.856.9
SequenceOne Letter Code:ASTTTNYT
Three Letter Code:H-D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH2
Labeling TargetChemokine receptor
AppearanceWhite lyophilised solid
Purity>98% (or refer to the Certificate of Analysis)
ActivityAntagonist
Source#Synthetic
Long-term Storage ConditionsSoluble in DMSO
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage ConditionsDry, dark and at 0 - 4 °C
Solubility-20 °C
InChIInChI=1S/C35H56N10O15/c1-13(36)29(54)41-22(12-46)32(57)43-26(16(4)49)34(59)45-27(17(5)50)35(60)44-25(15(3)48)33(58)40-21(11-23(37)52)30(55)39-20(10-18-6-8-19(51)9-7-18)31(56)42-24(14(2)47)28(38)53/h6-9,13-17,20-22,24-27,46-51H,10-12,36H2,1-5H3,(H2,37,52)(H2,38,53)(H,39,55)(H,40,58)(H,41,54)(H,42,56)(H,43,57)(H,44,60)(H,45,59)/t13-,14-,15-,16-,17-,20+,21+,22+,24+,25+,26+,27+/m1/s1
InChI KeyAKWRNBWMGFUAMF-ZESMOPTKSA-N
Isomeric SMILESC[C@H]([C@@H](C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@@H](C)N)O
ShelfLife>2 years if stored properly
References

A pre-HAART era placebo-controlled trial showed that DAPTA caused cognitive improvements, and a later analysis of stored samples suggests a clinically significant reduction in plasma viral load (K. Goodkin, University of Miami, personal communication). A more recent uncontrolled clinical trial reports that DAPTA substantially suppressed virus in persistently infected cellular reservoirs in both HAART experienced and naïve to treatment patients.

Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA)

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