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Z-IETD-FMK

Z-IETD-FMK is a selective and cell permeable caspase 8 inhibitor. It also inhibits caspase-10. The bis-methyl ester of Z-IETD-FMK blocked CD95-induced apoptosis.

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CAT#	HB00018
CAS	210344-98-2
Synonyms/Alias	IETD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Glu-2 = Glu(OMe); Asp-4 = Asp(OMe))
M.F/Formula	C30H43FN4O11
M.W/Mr.	654.6894
Sequence	Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F
Labeling Target	Caspase 8
Purity	95/98%
Activity	Inhibitor
Areas of Interest	Cancer

CAT#	Product Name	Inquiry
R1499	Magainin 1	Inquiry
R1170	Adrenomedullin (1-50), rat	Inquiry
R1777	β-Amyloid 1-34	Inquiry
R1781	β-Amyloid 1-9	Inquiry
HB00025	Fitc-ASTD-FMK	Inquiry

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Source#	Synthetic
Storage	-20°C
Solubility	Soluble in DMSO
Long-term Storage Conditions	-20 °C
InChI	InChI=1S/C30H43FN4O11/c1-6-17(2)25(35-30(43)46-16-19-10-8-7-9-11-19)28(41)32-20(12-13-23(38)44-4)27(40)34-26(18(3)36)29(42)33-21(22(37)15-31)14-24(39)45-5/h7-11,17-18,20-21,25-26,36H,6,12-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,40)(H,35,43)/t17-,18+,20-,21-,25-,26-/m0/s1
InChI Key	PHLCQASLWHYEMX-DEKIMQJDSA-N
Isomeric SMILES	CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
BoilingPoint	925.7±65.0 °C at 760 mmHg
Melting Point	N/A