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Pneumocandin B0

Pneumocandin B0 is the starting molecule for the first semisynthetic echinocandin antifungal drug, caspofungin acetate.

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CAT No: Z10-101-159

CAS No: 135575-42-7

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M.F/FormulaC50H80N8O17
M.W/Mr.1065.2
Labeling TargetBeta-(1,3)-glucan synthase
ApplicationPneumocandin B0 is a potent antifungal and inhibitor of Β-(1,3)-D-glucan synthesis.
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
Biological ActivityPneumocandin B0 is a lipohexapeptide composed of a 10R,12S-dimethylmyristoyl side chain and a hexapeptide core, which is produced by the fungus Glarea lozoyensis.
Areas of InterestImmunology & Inflammation
Cell Biology
Cancer
FunctionsA potent antifungal and inhibitor of ß-(1,3)-D-glucan synthesis
Long-term Storage ConditionsSoluble in DMSO
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage ConditionsDry, dark and at 0 - 4 °C
Solubility-20 °C
InChIInChI=1S/C50H80N8O17/c1-5-25(2)20-26(3)12-10-8-6-7-9-11-13-37(66)52-31-22-35(64)46(71)56-48(73)41-33(62)18-19-57(41)50(75)39(34(63)23-36(51)65)54-47(72)40(43(68)42(67)28-14-16-29(60)17-15-28)55-45(70)32-21-30(61)24-58(32)49(74)38(27(4)59)53-44(31)69/h14-17,25-27,30-35,38-43,46,59-64,67-68,71H,5-13,18-24H2,1-4H3,(H2,51,65)(H,52,66)(H,53,69)(H,54,72)(H,55,70)(H,56,73)/t25?,26?,27-,30-,31+,32+,33+,34-,35-,38+,39+,40+,41+,42+,43+,46-/m1/s1
InChI KeyDQXPFAADCTZLNL-ZESADUFFSA-N
Isomeric SMILESCCC(C)CC(C)CCCCCCCCC(=O)N[C@H]1C[C@H]([C@H](NC(=O)[C@@H]2[C@H](CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC1=O)[C@@H](C)O)O)[C@@H]([C@H](C4=CC=C(C=C4)O)O)O)[C@@H](CC(=O)N)O)O)O)O
BoilingPoint1442.9±65.0 °C at 760 mmHg
ShelfLife>2 years if stored properly
Melting PointN/A
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