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Plecanatide is a minimally absorbed agonist of guanylate cyclase C receptors in the intestine and is used for treatment of chronic constipation and irritable bowel syndrome. Plecanatide has not been linked to serum enzyme elevations during treatment or to episodes of clinically apparent liver injury.
CAT No: 10-101-170
CAS No: 467426-54-6
Synonyms/Alias: PLECANATIDE;Trulance;Guanilib;467426-54-6;UNII-7IK8Z952OK;plecanatida;Plecanatide [USAN:INN];7IK8Z952OK;HSDB 8405;SP-304 (SYNERGY);DTXSID60196933;(3-Glutamic acid(D>E))human uroguanylin (UGN);467426-54-6 (free base);L-Leucine, L-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-glutamyl-L-leucyl-L- cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4->12),(7->15)-bis(disulfide);(3-Glutamic acid(D>E))human uroguanylin;[3-glutamic acid(D>E)]human uroguanylin;plecanatidum;Plecanatide (Standard);TrulanceImmediate release;GTPL9069;CHEMBL2103867;A06AX07;DTXCID00119424;GLXC-26182;EX-A4131;AT41877;DB13170;HY-108741R;DA-56928;ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU CYCLIC (4->12),(7->15)-BIS(DISULFIDE);L-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-Glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-leucine cyclic (4-->12),(7-->15)-bis(disulfide);L-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-Glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-leucine cyclic (4adagger?2),(7adagger?5)-bis(disulfide);L-LEUCINE, L-ASPARAGINYL-L-alpha-ASPARTYL-L-alpha-GLUTAMYL-L-CYSTEINYL-L-alpha-GLUTAMYL-L-LEUCYL-L-CYSTEINYL-L-VALYL-L-ASPARAGINYL-L-VALYL-L-ALANYL-L-CYSTEINYL-L-THREONYLGLYCYL-L-CYSTEINYL-, CYCLIC (4-12),(7-15)-BIS(DISULFIDE);
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M.F/Formula | C65H104N18O26S4 |
M.W/Mr. | 1681.9 |
Sequence | One Letter Code:NDECELCVNVACTGCL Three Letter Code:H-Asn-Asp-Glu-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH |
Activity | Agonist |
Biological Activity | Plecanatide is a guanylate cyclase C agonist mechanistically similar to linaclotide. |
Target | Guanylate Cyclase-C |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
InChI | InChI=1S/C65H104N18O26S4/c1-25(2)15-34-55(98)80-41-24-113-110-21-38(58(101)77-37(65(108)109)16-26(3)4)71-44(87)20-69-62(105)50(30(10)84)83-61(104)40(78-51(94)29(9)70-63(106)48(27(5)6)81-57(100)35(18-43(68)86)76-64(107)49(28(7)8)82-60(41)103)23-112-111-22-39(59(102)73-32(53(96)75-34)11-13-45(88)89)79-54(97)33(12-14-46(90)91)72-56(99)36(19-47(92)93)74-52(95)31(66)17-42(67)85/h25-41,48-50,84H,11-24,66H2,1-10H3,(H2,67,85)(H2,68,86)(H,69,105)(H,70,106)(H,71,87)(H,72,99)(H,73,102)(H,74,95)(H,75,96)(H,76,107)(H,77,101)(H,78,94)(H,79,97)(H,80,98)(H,81,100)(H,82,103)(H,83,104)(H,88,89)(H,90,91)(H,92,93)(H,108,109)/t29-,30+,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,48-,49-,50-/m0/s1 |
InChI Key | NSPHQWLKCGGCQR-DLJDZFDSSA-N |
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