Murepavadin

Murepavadin (POL7080) is a highly potent, specific, macrocycle Pseudomonas antibiotic for the treatment of bacterial infections caused by Pseudomonas aeruginosa.

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CAT#R1900
Chemical Structure
CAS944252-63-5
Chemical Name(3R,9S,12S,15S,18S,21S,24S,27R,30S,33S,36S,39S,42S,45S)-15,18,24,27,33-pentakis(2-aminoethyl)-30-(3-aminopropyl)-36-[(2S)-butan-2-yl]-42-[(1R)-1-hydroxyethyl]-9-(hydroxymethyl)-21,39-bis(1H-indol-3-ylmethyl)-12-methyl-1,7,10,13,16,19,22,25,28,31,34,37,40,43-tetradecazatricyclo[43.3.0.03,7]octatetracontane-2,8,11,14,17,20,23,26,29,32,35,38,41,44-tetradecone
M.F/FormulaC73H112N22O16
M.W/Mr.1553.8
Sequencecyclo[Ala-Ser-D-Pro-Pro-Thr-Trp-Ile-Dab-Orn-D-Dab-Dab-Trp-Dab-Dab]
ApplicationBacterial infections
ActivityAntibiotic
Biological ActivityPathogen specific antimicrobial peptidomimetic with a novel, non-lytic mechanism of action, being the first in class of outer membrane protein targeting antibiotics, displaying a potent in vitro activity including carbapenemase-producing and colistin-resistant P. aeruginosa
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