[Lys(Ac)40]-Ac-a-Tubulin (29-50) - WGK(Biotin); TubK40(Ac)-WGK, biotin-labeled
[Lys(Ac)40]-Ac-a-Tubulin (29-50) - WGK(Biotin); TubK40(Ac)-WGK, biotin-labeled
This is an acetylated alpha tubulin peptide at lysine 40 with a C-terminal WG linker followed by a biotinylated lysine. The acetylation at lysine 40 of this peptide is shown to have a therapeutic interest in diseases involving altered intracellular transport such as Huntington's disease. Histone Deacetylase (HDAC) inhibitors have been shown to increase vesicular transport of brain derived neurotrophic factor thereby increasing acetylation of tubulin at lysine 40.
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| CAT# | X21204 |
| M.W/Mr. | 2918.2 |
| Sequence | One Letter Code: Ac-GIQPDGQMPSD-K(ac)-TIGGGDDSFNWG-K(biotin)
Three Letter Code: Ac-Gly-Ile-Gln-Pro-Asp-Gly-Gln-Met-Pro-Ser-Asp--Lys(ac)-Thr-Ile-Gly-Gly-Gly-Asp-Asp-Ser-Phe-Asn-Trp-Gly-Lys(biotin) |
| Storage | -20°C |
References | Dompierre JP. et al. J Neurosci 27(13):3571-3583 (2007). |
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