Humanin
Humanin is an endogenous peptide that exhibits anti-apoptotic and neuroprotective activities. Humanin is overexpressed in some cancers and could possibly be used as a biomarker.
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| CAT# | R1848 |
| CAS | 330936-69-1 |
| Synonyms/Alias | Humanin, human; Protein Humanin (human) |
| M.F/Formula | C121H205F3N34O34S2 |
| M.W/Mr. | 2801.26 |
| Sequence | One Letter Code: MAPRGFSCLLLLTSEIDLPVKRRA
Three Letter Code: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala |
| Application | Neuroprotective peptide |
| Appearance | White to off white powder |
| Purity | ≥95% |
| Activity | humanin activates formyl peptide receptor-like receptors 1 and 2 (FPRL1/2), inhibiting Bax-dependent apoptosis and suppressing JNK-mediated cell death. Humanin also inhibits amyloid-β (Aβ)-induced neuronal death in vitro and its effects in animal models of Alzheimer’s disease. |
| Storage | 20°C |
Solubility | Soluble in formic acid (1 mg/mL), 5% acetic acid. |
Shipping Condition | Ambient |
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