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Recent advances in high-resolution sequencing have led to the discovery of unique peptides derived from mitochondrial genome. 1-2 Currently 8 peptides are identified: humanin, mitochondrial open reading frame of the 12S tRNA-c (MOTS-c), and six small humanin-like peptides (SHLP1-6). 1-2 All of these peptides are released into cytosol from mitochondria. SHLP4 may promote cell proliferation in certain cells and could be involved in reduced apoptosis. 1-2
Peptide Library Construction and Screening
Powerful screening tools in biological and chemical research
M.W/Mr. | 3131.85 |
Sequence | One Letter Code: H-MLEVMFLVNRRGKICRVPFTFFNLSL-OH Three Letter Code: NH2-Met-Leu-Glu-Val-Met-Phe-Leu-Val-Asn-Arg-Arg-Gly-Lys-Ile-Cys-Arg-Val-Pro-Phe-Thr-Phe-Phe-Asn-Leu-Ser-Leu-COOH |
References | 1. Cobb L. J. et al., AGING 8 (4), 796-808 (2016). 2. Okada A. K. et al., Sci Reports 7 (7802), 1-10 (2017). . |
1. Peptides as Active Ingredients: A Challenge for Cosmeceutical Industry
2. TMEM16F and dynamins control expansive plasma membrane reservoirs
4. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
5. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
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