Rapamycin

Rapamycin is a macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production.

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CAT#	Z10-101-156
CAS	53123-88-9
Synonyms/Alias	Sirolimus; Rapamune; 53123-88-9; AY 22 989; I 2190A
M.F/Formula	C51H79NO13
M.W/Mr.	914.18
Labeling Target	Serine/threonine-protein kinase mTOR
Application	Rapamycin is a potent immunosuppressant, and have both antifungal and antineoplastic properties.
Appearance	White to off-white solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Activity	Inhibitor
Biological Activity	Rapamycin, a specific inhibitor of mTOR, has been shown to be useful in the treatment of certain diseases.
Areas of Interest	Immunosuppressant; Lymphangioleiomyomatosis (LAM)
Functions	Tfiiic-class transcription factor binding
Target	mTOR

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Storage	−20°C
Solubility	Soluble in DMSO, not in water
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions	Dry, dark and at 0 - 4 °C
Long-term Storage Conditions	-20 °C
Organism	Human
InChI	InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChI Key	QFJCIRLUMZQUOT-HPLJOQBZSA-N
Isomeric SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC
BoilingPoint	973.0±75.0 °C at 760 mmHg
ShelfLife	>2 years if stored properly
Melting Point	183-185°C