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Protirelin

Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

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CAT No: 10-101-51

CAS No: 24305-27-9

Synonyms/Alias: protirelin;24305-27-9;Thyroliberin;Lopremone;Synthetic TRH;Rifathyroin;Thypinone;Thyrotropin-releasing factor;TSH-releasing factor;Protirelina;Protireline;Thyrotropic-releasing factor;5-Oxo-L-prolyl-L-histidyl-L-prolinamide;Protirelinum;THYREL TRH;Relefact TRH;TRH;Abbott 38579;ABBOTT-38579;Protirelin, synthetic;Synthetic tsh-releasing factor;L-Pyroglutamyl-L-histidyl-L-prolinamide;5-oxo-pro-his-pro-nh2;L-Pyroglutamyl-L-histidyl-L-prolineamide;Protireline [INN-French];Protirelinum [INN-Latin];FDA 1725;L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-;Protirelina [INN-Spanish];CCRIS 2593;117217-40-0;Ro 8-6270/9;CHEBI:35940;Relefact TRH (TN);HOLO-TRANSFERRIN;Protirelin [USAN:INN:BAN:JAN];Protirelin tartrate;PROTIRELIN [INN];PROTIRELIN [JAN];EINECS 246-143-4;PROTIRELIN [USAN];(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide;PROTIRELIN [VANDF];5Y5F15120W;NSC-760113;PROTIRELIN [MART.];PROTIRELIN [WHO-DD];L-Pyroglutamyl-L-histidinyl-L-prolinamide;DTXCID403533;DTXSID0023533;PROTIRELIN [ORANGE BOOK];PROTIRELIN [EP MONOGRAPH];24305-27-9 (free base);A-38579;NSC 760113;NCGC00160616-01;Protireline (INN-French);Protirelinum (INN-Latin);Protirelina (INN-Spanish);PROTIRELIN (MART.);(S)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide;PROTIRELIN (EP MONOGRAPH);(2S)-N-[(2S)-1-[(2S)-2-aminocarbonylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxidanylidene-propan-2-yl]-5-oxidanylidene-pyrrolidine-2-carboxamide;pyroglutamyl-histidyl-prolylamide;Thyrefact;Trh-cambridge;Protirelin?;trh-sr;Synthetic TRF;UNII-5Y5F15120W;Human Transferrin;Relefact-TRH;TRH, Relefact;Stimu-TSH;Thyrotropin-releasing factor (pig);(2S)-N-((2S)-1-((2S)-2-aminocarbonylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxidanylidene-propan-2-yl)-5-oxidanylidene-pyrrolidine-2-carboxamide;(2S)-N-((2S)-1-((2S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide;PR 546;PR-546;Synthetic thyrotropin-releasing factor;Pyr-His-Pro-NH2;Abbott38579;PyroGlu-His-prolinamide;Thyroliberin TRH Merck;TSH-RF;TRH [MI];Thyrotropin Releasing Factor;CHEMBL1472;SCHEMBL33419;[3H]-TRH;GTPL2139;GTPL3836;Siderophilin;partially saturated;pyroglutamyl-histidyl-prolinamide;Protirelin (JP18/USAN/INN);SCHEMBL19825647;[3H]TRH (human, mouse, rat);V04CJ02;Thyrotropin Releasing Hormone TRH;BCP12450;HY-P0002;Synthetic thyrotopin releasing factor;Tox21_111939;BDBM50072394;s4680;AKOS015994636;AKOS040759052;CCG-268193;DB09421;FP33965;HS-2023;Protirelin;Thyrotropin-Releasing Hormone;(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide;DA-64226;L-Pyroglutamyl-L-histidyl-L-proline amide;CAS-24305-27-9;NS00006015;C03958;C74244;D00176;Prolinamide, 5-oxo-L-prolyl-L-histidyl-, L-;L-PYROGLUTAMYL-L-HISTIDYL-L-PROLINE-AMIDE;(Pyro)-L-glutamic acid-L-histidine-L-proline-NH2;A858244;EN300-27034140;Q24726011;Prolinamide, 1-[N-(5-oxo-L-prolyl)-L-histidyl]-, L-;pyroGlu-His-Pro-NH2 (or 5-oxo-L-prolyl-L-histidyl-L-prolinamide);(2S)-1-[(2S)-3-(1H-IMIDAZOL-4-YL)-2-{[(2S)-5-OXOPYRROLIDIN-2-YL]FORMAMIDO}PROPANOYL]PYRROLIDINE-2-CARBOXAMIDE;(2S)-1-[(2S)-3-(1H-imidazol-5-yl)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanoyl]pyrrolidine-2-carboxamide;(2S)-1-[(2S)-3-(imidazol-4-yl)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanoyl]pyrrolidine-2-carboxamide;(2S)-N-[(1S)-2-[(2S)-2-carbamoylpyrrolidino]-1-(1H-imidazol-5-ylmethyl)-2-keto-ethyl]-5-keto-pyrrolidine-2-carboxamide;1-(3-(1H-Imidazol-5-yl)-2-([(5-oxo-2-pyrrolidinyl)carbonyl]amino)propanoyl)-2-pyrrolidinecarboxamide #;1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyrrolylcarboxamido)propanoyl]tetrahydro-1H-2-pyrrolecarboxamide;2-Pyrrolidinecarboxamide, N-[1-[(2-carbamoyl-1-pyrrolidinyl)carbonyl]-2-imidazol-4-ylethyl]-5-oxo-,;2-Pyrrolidinecarboxamide, N-[1-[(2-Carbamoyl-1-pyrrolidinyl)carbonyl]-2-imidazol-4-ylethyl]-5-oxo-, (S,S,S)-;246-143-4;

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M.F/FormulaC16H22N6O4
M.W/Mr.362.38
SequenceOne Letter Code:XHP
Three Letter Code:H-Pyr-His-Pro-NH2
ApplicationTRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.
AppearanceSolid powder
TargetThyroid Hormone Receptor
Shipping ConditionRoom temperature in continental US; may vary elsewhere.
InChIInChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
InChI KeyXNSAINXGIQZQOO-SRVKXCTJSA-N
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