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A cyclic peptide that disrupts interaction between GluK2 (formally GluR6) and postsynaptic density protein 95 (PSD-95) through competing with the C terminal of GluK2 to bind the PDZ1 domain of PSD-95. It inhibits clustering of kainate receptors.
CAT No: R0842
CAS No: 1315378-73-4
Synonyms/Alias: PDZ1 Domain inhibitor peptide;1315378-73-4;(2S)-2-[[(2S)-2-[[(2S,5S,14S)-14-[[(2S)-6-amino-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]hexanoyl]amino]-2-[(1R)-1-hydroxyethyl]-3,8,15-trioxo-1,4,9-triazacyclopentadecane-5-carbonyl]amino]propanoyl]amino]-3-methylbutanoic acid;PDZ1 Domain inhibitor peptide TFA;HY-P1195;AKOS024456989;AS-85550;DA-76677;PD070684;CS-0028949;G17881;S-1315378-73-4;
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M.F/Formula | C38H61N9O11 |
M.W/Mr. | 819.9 |
Sequence | One Letter Code:YKKTEAV Three Letter Code:H-Tyr-Lys-Lys(1)-Thr-Glu(1)-Ala-Val-OH |
Appearance | White lyophilised solid |
Purity | >98 % |
Solubility | -20 °C |
InChI | InChI=1S/C38H61N9O11/c1-20(2)30(38(57)58)46-32(51)21(3)42-34(53)28-15-16-29(50)41-18-8-6-10-27(36(55)47-31(22(4)48)37(56)45-28)44-35(54)26(9-5-7-17-39)43-33(52)25(40)19-23-11-13-24(49)14-12-23/h11-14,20-22,25-28,30-31,48-49H,5-10,15-19,39-40H2,1-4H3,(H,41,50)(H,42,53)(H,43,52)(H,44,54)(H,45,56)(H,46,51)(H,47,55)(H,57,58)/t21-,22+,25-,26-,27-,28-,30-,31-/m0/s1 |
InChI Key | XXRRADBJCXMGOW-RMLJCASOSA-N |
Isomeric SMILES | C[C@H]([C@H]1C(=O)N[C@@H](CCC(=O)NCCCC[C@@H](C(=O)N1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CC=C(C=C2)O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)O)O |
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