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PDZ1 Domain inhibitor peptide

A cyclic peptide that disrupts interaction between GluK2 (formally GluR6) and postsynaptic density protein 95 (PSD-95) through competing with the C terminal of GluK2 to bind the PDZ1 domain of PSD-95. It inhibits clustering of kainate receptors.

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CAT#	R0842
CAS	1315378-73-4
M.F/Formula	C38H61N9O11
M.W/Mr.	819.95
Sequence	YKKTEAV (Modifications: Ala-6 = β-Ala, Cyclized = Lys-3 - Ala-6)
Appearance	White lyophilised solid
Purity	>98 %

CAT#	Product Name	Inquiry
R0887	(trans-Cinnamoyl)-YPGKF-NH2	Inquiry
R1933	TFFYGGSRGKRNNFKTEEYC	Inquiry
R1805	Angiotensin (1-7)	Inquiry
R1461	Jagged-1 188-204	Inquiry
R1487	LL-37, acetylated,amidated	Inquiry

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Storage	-20°C
Long-term Storage Conditions	-20 °C
InChI	InChI=1S/C38H61N9O11/c1-20(2)30(38(57)58)46-32(51)21(3)42-34(53)28-15-16-29(50)41-18-8-6-10-27(36(55)47-31(22(4)48)37(56)45-28)44-35(54)26(9-5-7-17-39)43-33(52)25(40)19-23-11-13-24(49)14-12-23/h11-14,20-22,25-28,30-31,48-49H,5-10,15-19,39-40H2,1-4H3,(H,41,50)(H,42,53)(H,43,52)(H,44,54)(H,45,56)(H,46,51)(H,47,55)(H,57,58)/t21-,22+,25-,26-,27-,28-,30-,31-/m0/s1
InChI Key	XXRRADBJCXMGOW-RMLJCASOSA-N
Isomeric SMILES	C[C@H]([C@H]1C(=O)N[C@@H](CCC(=O)NCCCC[C@@H](C(=O)N1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CC=C(C=C2)O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)O)O