Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2
CAT# | P4102 |
CAS | 112208-00-1 |
Synonyms/Alias | Pam3Cys-Ser-Lys-Lys-Lys-Lys-OH, Pam3CSK4; N-palmitoyl-5,6-dipalmitoylcysteinyl-seryl-lysine(4);N-palmitoyl-S-(2,3-bis(palmitoyloxy)propyl)cysteinyl-seryl-lysyl-lysyl-lysyl-lysine;Pam(3)-Cys-Ser-(Lys)4;Pam3Cys-Ser-(Lys)4;tripalmitoyl-cysteinyl-seryl-lysine(4) |
Chemical Name | (2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-3-[2,3-di(hexadecanoyloxy)propylsulfanyl]-2-(hexadecanoylamino)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acid |
Chemical Formula | C81H156N10O13S |
M.W/Mr. | 1510.26 |
Sequence | One Letter Code: XSKKKK Three Letter Code: palmitoyl-Cys(Unk)-Ser-Lys-Lys-Lys-Lys-OH |
Biological Activity | TLR1/TLR2 agonist. Synthetic analog of the triacylated N-terminal part of bacterial lipoproteins. Potent adjuvant in vivo. Potent activator of Balb/c splenocytes. |
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