Pam3CSK4

Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2

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CAT#P4102
CAS112208-00-1
Synonyms/AliasPam3Cys-Ser-Lys-Lys-Lys-Lys-OH, Pam3CSK4; N-palmitoyl-5,6-dipalmitoylcysteinyl-seryl-lysine(4);N-palmitoyl-S-(2,3-bis(palmitoyloxy)propyl)cysteinyl-seryl-lysyl-lysyl-lysyl-lysine;Pam(3)-Cys-Ser-(Lys)4;Pam3Cys-Ser-(Lys)4;tripalmitoyl-cysteinyl-seryl-lysine(4)
Chemical Name(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-3-[2,3-di(hexadecanoyloxy)propylsulfanyl]-2-(hexadecanoylamino)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acid
Chemical FormulaC81H156N10O13S
M.W/Mr.1510.26
SequenceOne Letter Code: XSKKKK
Three Letter Code: palmitoyl-Cys(Unk)-Ser-Lys-Lys-Lys-Lys-OH
Biological ActivityTLR1/TLR2 agonist. Synthetic analog of the triacylated N-terminal part of bacterial lipoproteins. Potent adjuvant in vivo. Potent activator of Balb/c splenocytes.
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