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LPYFD-NH2 is a neuroprotective peptide that binds to amyloid beta (Aβ) and protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo.
Peptide Library Construction and Screening
Powerful screening tools in biological and chemical research
M.F/Formula | C33H44N6O8 |
M.W/Mr. | 652.75 |
Sequence | LPYFD-NH2(Modifications: Asp-5 = C-terminal amide) |
Labeling Target | Amyloid beta (Aβ) |
Application | Neuroprotective peptide that binds to amyloid beta (Aβ). Protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo. Potential therapeutic in the treatment of Alzheimer's Disease. |
Solubility | -20 °C |
InChI | InChI=1S/C33H44N6O8/c1-19(2)15-23(34)33(47)39-14-6-9-27(39)32(46)38-26(17-21-10-12-22(40)13-11-21)31(45)37-25(16-20-7-4-3-5-8-20)30(44)36-24(29(35)43)18-28(41)42/h3-5,7-8,10-13,19,23-27,40H,6,9,14-18,34H2,1-2H3,(H2,35,43)(H,36,44)(H,37,45)(H,38,46)(H,41,42)/t23-,24-,25-,26-,27-/m0/s1 |
InChI Key | IZXBZWOUOODINS-IRGGMKSGSA-N |
Isomeric SMILES | CC(C)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CC(=O)O)C(=O)N)N |
BoilingPoint | N/A |
Melting Point | N/A |
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