Linaclotide D4
Isotope labelled Linaclotide. Linaclotide is a 14-amino acid peptide indicated for the treatment of adults with CC and IBS-C; agonist of guanylate cyclase C
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| CAT# | 10-101-194 |
| CAS | 851199-59-2 (non-d) |
| Synonyms/Alias | L-Cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-d4-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine Cyclic (1→6),(2→10),(5→13)-Tris(disulfide); 11: PN: WO2008151257 SEQID: 55 claimed protein-d4; 13: PN: WO2008151257 SEQID: 57 Claimed Protein-d4; 2074: PN: US20090062207 SEQID: 3 Claimed Protein-d4; 40: PN: WO2010065751 SEQID: 55 Claimed Protein-d4; 42: PN: WO2010065751 SEQID: 57 claimed protein-d4; 55: PN: US20100152118 SEQID: 55 Claimed Protein-d4; 55: PN: WO2011069038 SEQID: 55 Claimed Sequence-d4; 55: PN: WO2012037380 SEQID: 55 Unclaimed Protein-d4; 57: PN: WO2011069038 SEQID: 57 Claimed Sequence-d4; 57: PN: WO2012037380 SEQID: 57 Claimed Protein-d4 |
| M.F/Formula | C59H75N15O21S6D4 |
| M.W/Mr. | 1530.78 |
| Sequence | H–Cys1–Cys–Glu–Tyr–Cys–Cys–Asn–Pro–Ala*–Cys–Thr–Gly–Cys–Tyr–OH
(Disulfide bridge: 1-6; 2-10; 5-13) |
| Labeling Target | Natriuretic peptide receptor |
| Application | Linaclotide-d4 is the labeled analogue of a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation. |
| Appearance | White to Off-White Solid |
| Solubility | DMSO (Slightly), Water (Slightly) |
Melting Point | >222°C (dec.) |
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