IGF-1 DES is a truncated insulin-like growth factor-1 analog lacking the N-terminal tripeptide and used in receptor-binding research. Its shorter sequence displays altered affinity and signaling dynamics compared with full-length IGF-1. Researchers employ it in studies of receptor isoform engagement and downstream pathway modulation. The peptide aids fine dissection of IGF-1 structure–function relationships.
2. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
4. High fat diet and GLP-1 drugs induce pancreatic injury in mice
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