Exherin
ADH-1, an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion.
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| CAT# | HB00096 |
| Chemical Structure |  |
| CAS | 229971-81-7 |
| M.F/Formula | C22H34N8O6S2 |
| M.W/Mr. | 570.69 |
| Activity | Antagonist |
| Biological Activity | Exherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis. |
| Storage | Desiccate at -20°C |
Solubility | Soluble to 2.2 mg/mL in DMSO |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
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