Cortistatin 14 (mouse, rat)

Cortistatin-14 expressed in the cortex and hippocampus. Structural and functional similarities to somatostatin-14. Neuronal depressant and sleep-modulating properties in vivo. An important mediator of immunity and inflammation.

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CAT#	10-101-253
CAS	186901-48-4
Synonyms/Alias	Endogenous neuropeptide
M.F/Formula	C81H113N19O19S2
M.W/Mr.	1721.02
Sequence	One Letter Code: PCKNFFWKTFSSCK (Modifications: Disulfide bonds: 2-13) Three Letter Code: Pro-Cys-Lys-Asn-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys
Application	Cortistatin-14 may be used in competition binding assay with sst4 receptors (CHO-sst4) of CHO cells and sst1 receptors (CHO-sst1).[5]
Appearance	White or off-white lyophilized powder
Purity	≥97% (HPLC)

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Source#	Synthetic
Storage	−20°C
Solubility	1% acetic acid: 1 mg/mL
InChI	1S/C81H113N19O19S2/c1-46(103)67-80(117)95-59(38-49-24-9-4-10-25-49)73(110)96-62(42-101)76(113)97-63(43-102)77(114)99-65(79(116)90-56(81(118)119)30-15-18-34-84)45-121-120-44-64(98-68(105)53-31-19-35-86-53)78(115)89-54(28-13-16-32-82)69(106)94-61(40-66(85)104)75(112)92-57(36-47-20-5-2-6-21-47)71(108)91-58(37-48-22-7-3-8-23-48)72(109)93-60(39-50-41-87-52-27-12-11-26-51(50)52)74(111)88-55(70(107)100-67)29-14-17-33-83/h2-12,20-27,41,46,53-65,67,86-87,101-103H,13-19,28-40,42-45,82-84H2,1H3,(H2,85,104)(H,88,111)(H,89,115)(H,90,116)(H,91,108)(H,92,112)(H,93,109)(H,94,106)(H,95,117)(H,96,110)(H,97,113)(H,98,105)(H,99,114)(H,100,107)(H,118,119)/t46-,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,67+/m1/s1
InChI Key	DDRPLNQJNRBRNY-WYYADCIBSA-N
Canonical SMILES	CC(C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CC(=O)N)CCCCN)NC(=O)C6CCCN6)C(=O)NC(CCCCN)C(=O)O)CO)CO)CC7=CC=CC=C7)O