Cilengitide

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CAT#C5501
Chemical Structure
CAS188968-51-6
Synonyms/AliasCyclo(L-arginylglycyl-L-aspartyl-D-phenylalanyl-N-methyl-L-valyl)
M.F/FormulaC27H40N8O7
M.W/Mr.588.66
SequenceOne Letter Code: RGDFV
Biological ActivityPotent and selective inhibitor of integrins αvβ3 and αvβ5 (IC50 values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.
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