CAT# | C5501 |
Chemical Structure | |
CAS | 188968-51-6 |
Synonyms/Alias | Cyclo(L-arginylglycyl-L-aspartyl-D-phenylalanyl-N-methyl-L-valyl) |
M.F/Formula | C27H40N8O7 |
M.W/Mr. | 588.66 |
Sequence | One Letter Code: RGDFV |
Biological Activity | Potent and selective inhibitor of integrins αvβ3 and αvβ5 (IC50 values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity. |
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