Caspase-2 Inhibitor Z-VDVAD-FMK
Caspase-2 Inhibitor Z-VDVAD-FMK
Z-VDVAD-FMK is a synthetic peptide that irreversibly inhibits the activity of caspase-2. It attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells. Z-VDVAD-FMK can be used for both in vitro and in vivo studies.
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| CAT# | R1111 |
| CAS | 210344-95-9 |
| Synonyms/Alias | Benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone |
| M.F/Formula | C32H46FN5O11 |
| M.W/Mr. | 695.7 |
| Sequence | VDVAD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Asp-2 = Asp(OMe); Asp-5 = Asp(OMe)) |
| Labeling Target | Caspase-2 |
| Application | Z-VDVAD-FMK (Caspase-2 inhibitor) is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. |
| Appearance | White lyophilised solid |
| Purity | >98% |
| Activity | Inhibitor |
| Areas of Interest | Cell Biology
Cancer |
| Storage | -20°C |
Solubility | Soluble in DMSO |
Long-term Storage Conditions | -20 °C |
InChI | InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1 |
InChI Key | GBJVAVGBSGRRKN-JYEBCORGSA-N |
Isomeric SMILES | CC(C)[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(=O)OC)NC(=O)OCC1=CC=CC=C1 |
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