Bax inhibitor peptide V5

BAX Inhibiting Peptide V5 protects Bax against conformational changes and it also prevents mitochondrial translocation. In vitro analysis prove that peptide V5 prevents apoptosis, mediated by a number of agents including staurosporine, ultraviolet, and anti-cancer drug.

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CAT#	R1852
CAS	579492-81-2
Synonyms/Alias	BIP-V5
Chemical Name	(S)-6-amino-2-((Z)-((S)-2-((Z)-((S)-2-((Z)-(((S)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)(hydroxy)methylene)amino)-1-hydroxy-4-(methylthio)butylidene)amino)-1-hydroxy-4-methylpentylidene)amino)hexanoic acid
M.F/Formula	C27H50N6O6S
M.W/Mr.	586.8
Sequence	One Letter Code: VPMLK Three Letter Code: H-Val-Pro-Met-Leu-Lys-OH
Labeling Target	Apoptosis
Appearance	Crystalline solid
Purity	≥97% (HPLC)
Activity	Inhibitor
Areas of Interest	Cancer

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R2029	Enviomycin	Inquiry
R1369	Galanin (1-16), mouse, porcine, rat	Inquiry

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Source#	Synthetic
Storage	Store at -20°C.
Solubility	≥29.35mg/mL in DMSO,insoluble in EtOH, ≥91.4 mg/mL in H2O
Shipping Condition	Evaluation sample solution : ship with blue ice; All other available size: ship with RT , or blue ice upon request
Long-term Storage Conditions	-20 °C
InChI	InChI=1S/C27H50N6O6S/c1-16(2)15-20(24(35)31-19(27(38)39)9-6-7-12-28)32-23(34)18(11-14-40-5)30-25(36)21-10-8-13-33(21)26(37)22(29)17(3)4/h16-22H,6-15,28-29H2,1-5H3,(H,30,36)(H,31,35)(H,32,34)(H,38,39)/t18-,19-,20-,21-,22-/m0/s1
InChI Key	NHMUTADCTDDWPV-YFNVTMOMSA-N
Canonical SMILES	CC(C)CC(C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CCSC)NC(=O)C1CCCN1C(=O)C(C(C)C)N
Isomeric SMILES	CC(C)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)N
BoilingPoint	N/A
References	Sawatzky DA, et al. The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo. The American Journal of Pathology. 2006; 168(1):33-41.
Melting Point	N/A