Autocamtide-2-RelatedInhibitoryPeptide

Autocamtide-2-Related Inhibitory Peptide is a highly specific and potent inhibitor of CaMKII

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CAT#	R1857
CAS	167114-91-2
Synonyms/Alias	AIP, [Ala9]-Autocamtide 2
M.F/Formula	C64H116N22O19
M.W/Mr.	1497.74
Sequence	One Letter Code: KKALRRQEAVDAL Three Letter Code: Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu
Purity	≥97% (HPLC)
Activity	Selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC50 = 40 nM). Selective over PKC, PKA and CaM kinase IV (IC50 > 10 μM).

CAT#	Product Name	Inquiry
R1183	ALX 40-4C Trifluoroacetate	Inquiry
R1858	Jagged-1(188-204)TFA	Inquiry
R1853	Endomorphin 2	Inquiry
R1615	pGlu-Pro-Arg-MNA monoacetate	Inquiry
R1401	GRGDSPK	Inquiry

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Source#	Synthetic
Storage	-20 degrees Celsius away from light
Solubility	Soluble to 1 mg/ml in water
Shipping Condition	Wet ice in continental US; may vary elsewhere
InChI	1S/C65H114N20O21/c1-32(2)28-46(63(105)106)85-54(96)36(7)78-62(104)45(31-52(93)94)84-56(98)38(33(3)4)30-47(86)34(5)76-59(101)43(19-22-50(89)90)81-55(97)37(18-21-49(69)88)29-48(87)40(16-12-26-74-64(70)71)79-60(102)42(17-13-27-75-65(72)73)83-61(103)44(20-23-51(91)92)80-53(95)35(6)77-58(100)41(15-9-11-25-67)82-57(99)39(68)14-8-10-24-66/h32-46H,8-31,66-68H2,1-7H3,(H2,69,88)(H,76,101)(H,77,100)(H,78,104)(H,79,102)(H,80,95)(H,81,97)(H,82,99)(H,83,103)(H,84,98)(H,85,96)(H,89,90)(H,91,92)(H,93,94)(H,105,106)(H4,70,71,74)(H4,72,73,75)/t34-,35-,36-,37+,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1
InChI Key	COEHZSYVSXUBHI-CYZNULJVSA-N
Canonical SMILES	CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)CC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O