Angiotensin II Substrate
This is a tyrosine phosphorylated angiotensin II peptide with a substrate sequence specificity for chymase to act. This is an octapeptide hormone that is formed as a result of the action of human heart chymase, a chymotrypsin-like serine protease on the Phe-His bond of Angiotensin I. The ideal susbtrate for human heart chymase should contain this peptide sequence, and has been demonstrated that the Pro-Phe sequence in P2-P1 positions of peptide substrates is highly favored by leukocyte chymotrypsin-like proteinases such as chymases and cathepsin G.
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| CAT# | A15120 |
| M.W/Mr. | 1126.2 |
| Sequence | One Letter Code: DRV-pY-IHPF
Three Letter Code: H-Asp-Arg-Val-pTyr-Ile-His-Pro-Phe-OH |
| Storage | -20°C |
References | 1, Kinoshita A, et al. J Biol Chem 266(29): 19192-19197 (1991).
2, Ruzzene, M. et al. Eur. J. Biochem. 211, 289 (1993). |
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