YAP-TEAD Inhibitor 1
YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM).
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| CAT# | R1804 |
| Chemical Structure |  |
| CAS | 1659305-78-8 |
| M.F/Formula | C93H144ClN23O21S2 |
| M.W/Mr. | 2019.86 |
| Sequence | One Letter Code: Ac-VP-{Phe(3-Cl)}-{Hcy}-LRK-{Nle}-PASFCKPPE-NH2 (Disulfide bridge:Hcy4-Cys13)
Three Letter Code: Ac-{Val}{Pro}{Phe(3-Cl)}{Hcy}{Leu}{Arg}{Lys}{Nle}{Pro}{Ala}{Ser}{Phe}{Cys}{Lys}{Pro}{Pro}{Glu}-NH2 (Disulfide bridge:Hcy4-Cys13) |
| Storage | Desiccate at -20°C |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
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