Trofinetide

Trofinetide is a synthetic analog of glycine–proline–glutamate, the N-terminal tripeptide of the insulin-like growth factor 1 protein, and has demonstrated clinical benefit in phase 2 studies in Rett syndrome.

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CAT#	R1973
CAS	853400-76-7
Synonyms/Alias	Trofinetide 853400-76-7 NNZ-2566 DAYBUE Trofinetide [INN] L-Glutamic acid, glycyl-2-methyl-L-prolyl- UNII-Z2ME8F52QL ACP-2566 Z2ME8F52QL Trofinetide [USAN] glycyl-L-2-methylprolyl-L-glutamic acid Trofinetide(NNZ2566) Glycyl-2-methyl-L-prolyl-L-glutamic acid (2S)-2-[[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carbonyl]amino]pentanedioic acid Trofinetide (>90%) ((S)-1-glycyl-2-methylpyrrolidine-2-carbonyl)-L-glutamic acid trofinetida trofinetidum Glycyl-2-methyl-L-prolyl-L-glutamic Acid; Glycyl-L-2-methylprolyl-L-glutamic Acid; NNZ 2566 NNZ 2566 Daybue (TN) Trofinetide (USAN/INN) Trofinetide [USAN:INN] TROFINETIDE [WHO-DD] CHEMBL197084 SCHEMBL1170014 GTPL12482 NNZ2566 CHEBI:229599 DTXSID101336041 GLXC-15737 EX-A7815 WHO 10076 AKOS030607026 analogue 4 [PMID: 15837309] AT37725 CS-8154 DB06045 DA-68364 HY-16757 MS-24628 glycyl-alpha-methyl-L-prolyl-L-glutamic acid D12400 Q27294917
Chemical Name	(2S)-2-[[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carbonyl]amino]pentanedioic acid
M.F/Formula	C13H21N3O6
M.W/Mr.	315.32
Sequence	GXE
Appearance	Solid

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Storage	Sealed storage, away from moisture and light, under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solubility	Soluble to 100 mM in water and to 50 mM in DMSO with gentle warming
InChI	InChI=1S/C13H21N3O6/c1-13(5-2-6-16(13)9(17)7-14)12(22)15-8(11(20)21)3-4-10(18)19/h8H,2-7,14H2,1H3,(H,15,22)(H,18,19)(H,20,21)/t8-,13-/m0/s1
InChI Key	BUSXWGRAOZQTEY-SDBXPKJASA-N
Canonical SMILES	CC1(CCCN1C(=O)CN)C(=O)NC(CCC(=O)O)C(=O)O
Isomeric SMILES	C[C@]1(CCCN1C(=O)CN)C(=O)N[C@@H](CCC(=O)O)C(=O)O
BoilingPoint	655.4±55 ℃
Melting Point	144 ℃