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(R)-MG132 is a potent, reversible, and cell-permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively.
CAT No:R1874
CAS No:1211877-36-9
Chemical Name:benzyl N-[(2S)-4-methyl-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
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M.F/Formula | C26H41N3O5 |
M.W/Mr. | 475.6 |
Sequence | One Letter Code: Cbz-LLL Three Letter Code: Cbz-Leu-D-Leu-Leu-al |
Purity | ≥97% by HPLC |
Activity | Potent 20S proteasome inhibitor (IC50 = 0.22 nM). Exhibits cytostatic and cytotoxic effects in tumor cells in vitro. |
Long-term Storage Conditions | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
Shipping Condition | Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request. |
InChI | InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1 |
InChI Key | TZYWCYJVHRLUCT-ZRBLBEILSA-N |
Canonical SMILES | CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 |
Isomeric SMILES | CC(C)C[C@@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1 |
2. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
4. Peptides as Active Ingredients: A Challenge for Cosmeceutical Industry
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