Pyr-Gly-OH

Name: Pyr-Gly-OH
Brand: Creative Peptides
SKU: P7103
Availability: MadeToOrder

Pyr-Gly-OH combines pyroglutamate with glycine to create a simple blocked dipeptide. Pyroglutamate modifies charge and resistance to aminopeptidases. Glycine provides high conformational freedom. The peptide is used as a minimal model for pyroglutamyl effects on small-peptide structure.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: P7103

CAS No:29227-88-1

Synonyms/Alias:PYR-GLY-OH;Pyroglutamylglycine;29227-88-1;Pglu-gly;Pyroglu-gly-OH;2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]acetic acid;Edp pyroglu-glyoh;N-(5-Oxo-L-prolyl)glycine;Epidermal dipeptide pyroglu-glyoh;L-Pyroglutamyl-Gly;Pglu-Gly-OH;MFCD00191010;5-oxo-L-prolylglycine;Pyr-Gly-OH, AldrichCPR;SCHEMBL158182;CHEMBL508905;CHEBI:83067;DTXSID70951838;Glycine, N-(5-oxo-L-prolyl)-;HLPLTUJPJMFPMP-BYPYZUCNSA-N;HY-P4859;AKOS006275760;DA-67036;FP108243;(S)-(5-Oxopyrrolidine-2-carbonyl)glycine;CS-0674788;F87904;(S)-2-(5-oxopyrrolidine-2-carboxamido)acetic acid;Q63408685;N-[Hydroxy(5-hydroxy-3,4-dihydro-2H-pyrrol-2-yl)methylidene]glycine;

Custom Peptide Synthesis

cGMP Peptide

Registration of APIs
CMC information required for an IND

IND and NDA support
Drug master files (DMF) filing

M.F/Formula

C7H10N2O4

M.W/Mr.

186.17

Sequence

One Letter Code:XG
Three Letter Code:H-Pyr-Gly-OH

InChI

InChI=1S/C7H10N2O4/c10-5-2-1-4(9-5)7(13)8-3-6(11)12/h4H,1-3H2,(H,8,13)(H,9,10)(H,11,12)/t4-/m0/s1

InChI Key

HLPLTUJPJMFPMP-BYPYZUCNSA-N

1. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment

2. C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients

3. Cationic cell-penetrating peptides are potent furin inhibitors

4. Olfactory receptor based piezoelectric biosensors for detection of alcohols related to food safety applications

5. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy

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