Omiganan Pentahydrochloride (MBI 226), a Topical 12-Amino-Acid Cationic Peptide, has good antimicrobial activity and bactericidal activity.
CAT# | 10-101-93 |
CAS | 269062-93-3 |
Background | omiganan pentahydrochloride, a pentahydrochloride salt of omiganan, is a synthetic cationic antimicrobial peptide with wide-spectrum activity against both gram-positive and gram-negative bacteria and fungi. Omiganan pentahydrochloride, an analog of indolicidin, acts by disrupting bacterial cytoplasmic membranes and has been tested in a topical gel for the prevention of catheter-related bloodstream infections. |
Synonyms/Alias | L-Isoleucyl-L-leucyl-L-arginyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-arginyl-L-arginyl-L-lysinamide hydrochloride |
M.F/Formula | C90H127N27O12·5HCl |
M.W/Mr. | 1961.45 |
Sequence | H-Ile-Leu-Arg-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-Lys-NH2. 5HCl |
Labeling Target | Bacterial |
Application | Omiganan pentahydrochloride, a bactericidal and fungicidal cationic peptide being developed as a topical gel for prevention of catheter-associated infections, inhibited commonly occurring fungal pathogens. |
Appearance | White powder |
Purity | Purity (HPLC) ≥98.0% |
Biological Activity | Omiganan pentahydrochloride is a cationic peptide with antibacterial activity. |
Areas of Interest | Infection |
Target | Antimicrobial |
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