Omiganan Pentahydrochloride

Omiganan Pentahydrochloride (MBI 226), a Topical 12-Amino-Acid Cationic Peptide, has good antimicrobial activity and bactericidal activity.

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CAT#10-101-93
CAS269062-93-3
Background

omiganan pentahydrochloride, a pentahydrochloride salt of omiganan, is a synthetic cationic antimicrobial peptide with wide-spectrum activity against both gram-positive and gram-negative bacteria and fungi. Omiganan pentahydrochloride, an analog of indolicidin, acts by disrupting bacterial cytoplasmic membranes and has been tested in a topical gel for the prevention of catheter-related bloodstream infections.

Synonyms/AliasL-Isoleucyl-L-leucyl-L-arginyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-arginyl-L-arginyl-L-lysinamide hydrochloride
M.F/FormulaC90H127N27O12·5HCl
M.W/Mr.1961.45
SequenceH-Ile-Leu-Arg-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-Lys-NH2. 5HCl
Labeling TargetBacterial
ApplicationOmiganan pentahydrochloride, a bactericidal and fungicidal cationic peptide being developed as a topical gel for prevention of catheter-associated infections, inhibited commonly occurring fungal pathogens.
AppearanceWhite powder
PurityPurity (HPLC) ≥98.0%
Biological ActivityOmiganan pentahydrochloride is a cationic peptide with antibacterial activity.
Areas of InterestInfection
TargetAntimicrobial
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