K-(D-1-Nal)-FwLL-NH2

K-(D-1-Nal)-FwLL-NH2 is a high affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively), which blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

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CAT#	R0816
CAS	1394288-22-2
M.F/Formula	C51H67N9O6
M.W/Mr.	902.13
Sequence	KXFWLL(Modifications: X=D-1-Nal,Trp-4 = D-Trp, Leu-6 = C-terminal amide)
Labeling Target	Ghrelin receptor
Application	K-(D-1-Nal)-FwLL-NH2 is an inverse agonist of the ghrelin receptor.
Purity	>98 %
Activity	Agonist

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Storage	-20°C
InChI	InChI=1S/C51H67N9O6/c1-31(2)25-41(46(54)61)56-48(63)42(26-32(3)4)58-51(66)45(29-36-30-55-40-23-11-10-21-38(36)40)60-49(64)43(27-33-15-6-5-7-16-33)59-50(65)44(57-47(62)39(53)22-12-13-24-52)28-35-19-14-18-34-17-8-9-20-37(34)35/h5-11,14-21,23,30-32,39,41-45,55H,12-13,22,24-29,52-53H2,1-4H3,(H2,54,61)(H,56,63)(H,57,62)(H,58,66)(H,59,65)(H,60,64)/t39-,41-,42-,43-,44+,45+/m0/s1
InChI Key	NCMQVOQOKBIHPA-MHRDGXECSA-N
Isomeric SMILES	CC(C)C[C@@H](C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@@H](CC4=CC=CC5=CC=CC=C54)NC(=O)[C@H](CCCCN)N