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PG 106 is a selective antagonist of human melanocortin receptor 3 (hMC3R), and shows no activity at hMC4 receptors and hMC5 receptors. Therefore, it may be used to differentiate the substructural features responsible for selectivity at the hMC3R, hMC4R, and hMC5R.
CAT No: R0980
CAS No: 944111-22-2
Synonyms/Alias: 944111-22-2;PG106;(3S,6S,9R,16S,24S)-16-(2-Acetamidohexanoylamino)-6-[3-(diaminomethylideneamino)propyl]-3-(1H-indol-3-ylmethyl)-9-(naphthalen-2-ylmethyl)-2,5,8,11,15,18-hexaoxo-1,4,7,10,14,19-hexazacyclotetracosane-24-carboxamide;PG 106 TFA;AKOS024458418;DA-66643;PD079778;
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M.F/Formula | C51H69N13O9 |
M.W/Mr. | 1008.2 |
Sequence | One Letter Code:XDXXRWK Three Letter Code:Ac-DL-Nle-Asp(1)-bAla-D-2Nal-Arg-Trp-Lys(1)-NH2 |
Labeling Target | Human melanocortin receptor 3 (hMC3R) |
Appearance | White lyophilised solid |
Purity | >98% |
Activity | Antagonist |
InChI | InChI=1S/C51H69N13O9/c1-3-4-15-38(59-30(2)65)47(70)64-42-28-44(67)55-22-10-9-17-37(45(52)68)61-50(73)41(27-34-29-58-36-16-8-7-14-35(34)36)63-48(71)39(18-11-23-57-51(53)54)62-49(72)40(60-43(66)21-24-56-46(42)69)26-31-19-20-32-12-5-6-13-33(32)25-31/h5-8,12-14,16,19-20,25,29,37-42,58H,3-4,9-11,15,17-18,21-24,26-28H2,1-2H3,(H2,52,68)(H,55,67)(H,56,69)(H,59,65)(H,60,66)(H,61,73)(H,62,72)(H,63,71)(H,64,70)(H4,53,54,57)/t37-,38?,39-,40+,41-,42-/m0/s1 |
InChI Key | ZFZDDBJAFMOQSH-JHMPFZGISA-N |
Isomeric SMILES | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCNC1=O)CC2=CC3=CC=CC=C3C=C2)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C |
BoilingPoint | N/A |
Melting Point | N/A |
3. TMEM16F and dynamins control expansive plasma membrane reservoirs
5. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
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