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CAT No: R2508
CAS No: 1456699-27-6
Synonyms/Alias: Mifomelatide;1456699-27-6;mifomelatide [INN];ZCH45RV64X;(3S,11S,14S,17S,20R,23S)-3-[[(2S)-2-acetamidohexanoyl]amino]-N-[(2R)-1-[(2R)-2-carbamoylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-17-[3-(diaminomethylideneamino)propyl]-14-(1H-indol-3-ylmethyl)-20-(naphthalen-2-ylmethyl)-2,5,13,16,19,22-hexaoxo-1,6,12,15,18,21-hexazabicyclo[21.3.0]hexacosane-11-carboxamide;D-Prolinamide, N-acetyl-L-norleucyl-L-alpha-aspartyl-L-prolyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysyl-D-valyl-, (2-->7)-lactam;
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M.F/Formula | C63H87N15O11 |
M.W/Mr. | 1230.5 |
Sequence | One Letter Code:XDPXRWKVP Three Letter Code:Ac-Nle-Asp(1)-Pro-D-2Nal-Arg-Trp-Lys(1)-D-Val-D-Pro-NH2 |
InChI | InChI=1S/C63H87N15O11/c1-5-6-19-44(70-37(4)79)55(82)75-49-34-52(80)67-27-12-11-21-45(57(84)76-53(36(2)3)62(89)77-29-14-23-50(77)54(64)81)71-59(86)48(33-41-35-69-43-20-10-9-18-42(41)43)73-56(83)46(22-13-28-68-63(65)66)72-58(85)47(74-60(87)51-24-15-30-78(51)61(49)88)32-38-25-26-39-16-7-8-17-40(39)31-38/h7-10,16-18,20,25-26,31,35-36,44-51,53,69H,5-6,11-15,19,21-24,27-30,32-34H2,1-4H3,(H2,64,81)(H,67,80)(H,70,79)(H,71,86)(H,72,85)(H,73,83)(H,74,87)(H,75,82)(H,76,84)(H4,65,66,68)/t44-,45-,46-,47+,48-,49-,50+,51-,53+/m0/s1 |
InChI Key | MBDALAXLRYJVAO-AXWWBJHISA-N |
1. TMEM16F and dynamins control expansive plasma membrane reservoirs
2. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
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