Huwentoxin XVI

Huwentoxin-XVI, a 39 amino acids peptide, is potent and selective N-type Ca2+ channel blocker (IC50 ~ 60 nM). It can selectively and reversibly block N-type Ca2+ channels, but it does not block T-type Ca2+ channels, K+ channels or Na+ channels. It shows analgesic effects in vivo.

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CAT#R1055
CAS1600543-88-1
Background

HWTX-XVI, a 39-residue polypeptide with three disulfide bonds, was purified and characterized from Chinese tarantula venom. HWTX-XVI could block the twitch response of rat vas deferens to low-frequency electrical stimulation. HWTX-XVI selectively inhibited N-type calcium channels in DRG neurons but had no effect on other channels.  >> Read More

M.F/FormulaC196H292N50O56S6
M.W/Mr.4437.13
SequenceCIGEGVPCDENDPRCCSGLVCLKPTLHGIWYKSYYCYKK(Disulfide bridge: Cys1- and Cys6,Cys8 and Cys21,Cys15 and Cys36)
Labeling TargetCalcium Channel
AppearanceWhite lyophilised solid
Purity>98%
ActivityBlocker
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