Triptorelin

Triptorelin

Triptorelin is a gonadotropin releasing hormone (GnRH) agonist that is a potent inhibitor of the synthesis of testosterone (in men) and estrogen (in women) and is used to treat advanced prostate cancer.

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CAT No: R1945

CAS No: 57773-63-4

Synonyms/Alias: TRIPTORELIN;57773-63-4;Triptoreline;Triptorelina;Arvekap;Triptorelinum;Triptodur;(D-Trp6)-GnRH;Triptorelin pamoate;Decapeptyl;tryptorelin;Diferelin;Trelstar;D-Tryptophan-LH-RH;Diphereline;pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2;UNII-9081Y98W2V;CHEBI:63633;CL 118532;CL-118532;CL 118,532;BIM 21003;Wy 42422;[D-Trp6]-LH-RH;Triptoreline [INN-French];Triptorelinum [INN-Latin];Triptorelina [INN-Spanish];AY-25650;DTXSID2048375;Pamorelin;Salvacyl;Trelstar depot;9081Y98W2V;5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycinamide;Trelstar LA;(D-Trp6)-LH-RH;Triptoreline (INN-French);Triptorelinum (INN-Latin);Triptorelina (INN-Spanish);6-D-tryptophan-LH-RH;D-Trp-6-LH-RH;LHRH, Tryptophyl(6)-;Wy 42462;GnRH, Trp(6)-;LHRH, Trp(6)-;Detryptoreline;AY 25650;Trellasar;Moapar;Triptorelin [USAN:INN:BAN];Decapeptyl SR;Pamorelin LA;Triptorelin (swine);Wy-42462;D-Trp6-LHRH;Debio-8206;Triptorelin (USAN/INN);TRIPTORELIN (MART.);GTPL1177;SCHEMBL5079698;CHEMBL1201334;DTXCID8028349;SCHEMBL22289009;L02AE04;VXKHXGOKWPXYNA-PGBVPBMZSA-N;HMS2090C17;EX-A3857;BIM-21003;AKOS030213249;CS-5745;DB06825;NCGC00167301-01;NCGC00167301-02;AS-71149;BN-52014;DA-48936;HY-12551;CL-118,532;C75704;D06247;[D-Trp6]-LH-RH, >=97% (HPLC), powder;AB01275488-01;6-D-Tryptophanluteinizing Hormone-releasing Factor;A936467;EN300-18527985;pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-GlyNH2;Q1992452;BRD-K62685538-001-01-7;(S)-1-((3S,6S,9S,12S,15R,18S,21S)-3-((1H-imidazol-5-yl)methyl)-6,15-bis((1H-indol-3-yl)methyl)-21-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-18-isobutyl-1,4,7,10,13,16,19-heptaoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11,14,17,20-heptaazadocosan-22-oyl)-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide;Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolyl-;

Chemical Name: (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

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M.F/Formula	C64H82N18O13
M.W/Mr.	1311.4
Sequence	One Letter Code:XHWSYWLRPG Three Letter Code:H-Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
Appearance	Solid powder
Biological Activity	Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor. It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells.
Target	Gonadotropin-releasing hormone (GnRH)

Long-term Storage Conditions	Soluble in DMSO
InChI	InChI=1S/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)/t44-,45-,46-,47-,48+,49-,50-,51-,52-/m0/s1
InChI Key	VXKHXGOKWPXYNA-PGBVPBMZSA-N
Canonical SMILES	CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8
Isomeric SMILES	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)[C@@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
References	A total of 22 months' worth of data were analyzed (or 1 041 638 total items, monthly average 47 347 items). Goserelin; leuprorelin, and triptorelin are the medicines most used by total quantity in the study period. Simple descriptive statistics show that mean values have declined during the pandemic. The Interrupted Time Series (ARIMA Modeling) shows declining trends. Ravina Barrett, Robert Barrett, Kalyan Dhar, Gonadorelins adherence in prostate cancer: A time-series analysis of England’s national prescriptions during the COVID-19 pandemic (from Jan 2019 to Oct 2020)

1. Novel Peptide-Based PD1 Immunomodulators Demonstrate Efficacy in Infectious Disease Vaccines and Therapeutics

2. An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I

3. Zeta-potential-changing nanoparticles conjugated with cell-penetrating peptides for enhanced transfection efficiency

4. Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

5. The effect of sex on immune responses to a homocitrullinated peptide in the DR4-transgenic mouse model of Rheumatoid Arthritis

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