Furin Inhibitor II

Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo.

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CAT#	R1834
CAS	673202-67-0
Synonyms/Alias	Hexa-D-arginine
M.F/Formula	C36H75N25O6
M.W/Mr.	954.1
Sequence	One Letter Code: RRRRRR (Modifications: Arg-6 = C-terminal amide, Arg-1,2,3,4,5,6=D-Arg) Three Letter Code: H-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2
Purity	98% by HPLC

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Source#	Synthetic
Storage	Long-term storage is recommended at -20 ºC.
Solubility	H2O : 50 mg/mL (52.40 mM; Need ultrasonic) DMSO : 5 mg/mL (5.24 mM; Need ultrasonic)
Shipping Condition	Shipped at room temperature
InChI	InChI=1S/C36H75N25O6/c37-19(7-1-13-51-31(39)40)26(63)58-21(9-3-15-53-33(43)44)28(65)60-23(11-5-17-55-35(47)48)30(67)61-24(12-6-18-56-36(49)50)29(66)59-22(10-4-16-54-34(45)46)27(64)57-20(25(38)62)8-2-14-52-32(41)42/h19-24H,1-18,37H2,(H2,38,62)(H,57,64)(H,58,63)(H,59,66)(H,60,65)(H,61,67)(H4,39,40,51)(H4,41,42,52)(H4,43,44,53)(H4,45,46,54)(H4,47,48,55)(H4,49,50,56)/t19-,20-,21-,22-,23-,24-/m1/s1
InChI Key	BMLTZEAFQLJTIZ-TZNXUKFXSA-N
Canonical SMILES	C(CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)N)N)CN=C(N)N
Isomeric SMILES	C(C[C@H](C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N)N)CN=C(N)N