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α-Conotoxin AuIB

Selective antagonist of α3β4 nicotinic acetylcholine receptors

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CAT#R1921
CAS216299-21-7
Synonyms/Aliasalfa-Conotoxin AuIB
Chemical Name2-[53-[(2-aminoacetyl)amino]-18-(2-amino-2-oxoethyl)-27-benzyl-6-carbamoyl-21-(1-hydroxyethyl)-48-(hydroxymethyl)-45-[(4-hydroxyphenyl)methyl]-24-methyl-8,11,17,20,23,26,29,32,38,44,47,50,52-tridecaoxo-3,4,55,56-tetrathia-7,10,16,19,22,25,28,31,37,43,46,49,51-tridecazapentacyclo[28.20.7.012,16.033,37.039,43]heptapentacontan-9-yl]acetic acid
M.F/FormulaC65H89N17O21S4
M.W/Mr.1572.76
SequenceOne Letter Code: GCCSYPPCFAXNPDC
Three Letter Code: H-Gly-DL-Cys(1)-DL-Cys(2)-DL-Ser-DL-Tyr-DL-Pro-DL-Pro-DL-Cys(1)-DL-Phe-DL-Ala-DL-xiThr-DL-Asn-DL-Pro-DL-Asp-DL-Cys(2)-NH2
AppearancePowder
ActivityAntagonist
Biological ActivitySelective antagonist of α3β4 nicotinic acetylcholine receptors. Displays > 100-fold selectivity over other receptor subunit combinations including α2β2, α2β4, α3β2, α4β2, α4β4 and α1β1γδ.
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