MTP-131; RX-31; SS-31 Elamipretide
MTP-131; RX-31; SS-31 Elamipretide
Elamipretide is a cardiolipin peroxidase inhibitor and mitochondria-targeting peptide under the development of Stealth BioTherapeutics. It can Improve left Ventricular and Mitochondrial Function. Elamipretide can alleviate mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. It can prevent both iHTM and GTM(3) cells from sustained oxidative stress induced by H(2)O(2). Phase II clinical trials for the treatment of Chronic heart failure and Mitochondrial myopathies are ongoing.
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| CAT# | R1809 |
| Chemical Structure |  |
| CAS | 736992-21-5 |
| M.F/Formula | C32H49N9O5 |
| M.W/Mr. | 639.80 |
| Sequence | One Letter Code: T-Dab-Dab-Dab-Dab-d-FL-Dab-Dab-T (Lactam: Dab3-Thr9)
three Letter Code: Thr-Dab-Dab-Dab-Dab-d-Phe-Leu-Dab-Dab-Thr (Lactam: Dab3-Thr9) |
| Activity | Inhibitor |
| Biological Activity | Elamipretide, also known as MTP-131 or D-Arg-Dmt-Lys-Phe-NH2,is a cardiolipin peroxidase inhibitor and mitochondria-targeted peptide. MTP-131 alleviates mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. MTP-131 could prevent both iHTM and GTM(3) cells from sustained oxidative stress induced by H(2)O(2). |
| Target | Cardiolipin Peroxidase |
| Storage | Desiccate at -20°C |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
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