DAMME
DAMME is a stable synthetic analog of methionine enkephalin. Actions are similar to those of methionine enkephalin. It can be reversed by narcotic antagonists such as naloxone. It is one of the best-known analogs that has undergone fairly extensive clinical testing.
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| CAT# | 10-101-79 |
| CAS | 64854-64-4 (net) |
| Background | DAMME (DA) is a guanine, often referred to as FK 33-824 (FK), which is a long-acting enkephalin analog. Natural enkephalin is metabolized faster in the body and can only exert weak and transient analgesic effects. The synthetic enkephalin analog DAMME is less sensitive to metabolic breakdown and can be present in the body for a long time, so it has a long-lasting and effective analgesic effect on animals after systemic and enteral administration. It has an analgesic effect on inflammatory pain, neuropathic pain and cancer pain. Therefore, it has a good prospect in the field of analgesia. ?>> Read More |
| Synonyms/Alias | D-Ala(2); MePhe(4); Met(0)-ol-enkephalin; FK 33-824; FK-33-824; FK-33824; CID11758339; DL-tyrosyl-DL-alanyl-glycyl-N-methyl-DL-phenylalanyl-S-oxo-DL-methioninol;Tyr Ala Gly MePhe Met OH; Tyr-Ala-Gly-MePhe-Met-OH |
| Chemical Name | 2-amino-N-[1-[[2-[[1-[(1-hydroxy-4-methylsulfinylbutan-2-yl)amino]-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide |
| M.F/Formula | C29H41N5O7S |
| M.W/Mr. | 603.73 |
| Sequence | One Letter Code: YAGFX
Three Letter Code: H-DL-Tyr-DL-Ala-Gly-DL-N(Me)Phe-DL-Met(O)-ol |
| Application | DAMME exerts a potent analgesic effect after systemic administration. |
| Areas of Interest | Analgesics |
| Source# | Synthetic |
Long-term Storage Conditions | ?20°C |
InChI | InChI=1S/C29H41N5O7S/c1-19(32-28(39)24(30)15-21-9-11-23(36)12-10-21)27(38)31-17-26(37)34(2)25(16-20-7-5-4-6-8-20)29(40)33-22(18-35)13-14-42(3)41/h4-12,19,22,24-25,35-36H,13-18,30H2,1-3H3,(H,31,38)(H,32,39)(H,33,40) |
InChI Key | HYZHONGSQNXMPH-UHFFFAOYSA-N |
Canonical SMILES | CC(C(=O)NCC(=O)N(C)C(CC1=CC=CC=C1)C(=O)NC(CCS(=O)C)CO)NC(=O)C(CC2=CC=C(C=C2)O)N |
BoilingPoint | 1033.4±65.0 °C at 760 mmHg |
Melting Point | N/A |
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