Glatiramer acetate
Glatiramer acetate consists of the acetate salts of synthetic polypeptides, containing four naturally occurring amino acids: L-glutamic acid, L-alanine, L-tyrosine, and L-lysine with an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. The average molecular weight of glatiramer acetate is 5,000-9,000 daltons. It is an immunomodulator, licensed in much of the world for reduced frequency of relapses in relapsing-remitting multiple sclerosis
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| CAT# | 10-101-164 |
| CAS | 147245-92-9 |
| Synonyms/Alias | COP-1;Copolymer-1;Copoylmer 1 |
| M.F/Formula | C254H422N70O72 |
| M.W/Mr. | 7000.0 Da (range 5000-9000) |
| Sequence | EAYKAAEKAYAAKEAAKEAAKAKAEKKAAYAKAKAAKYEKKAKKAAAEYKKK |
| Labeling Target | HLA class II histocompatibility antigen, DRB1-1 beta chain |
| Application | Glatiramer is for reduction of the frequency of relapses in patients with Relapsing-Remitting Multiple Sclerosis. |
| Activity | Binder |
| Biological Activity | Glatiramer acetate, a synthetic analogue of myelin basic protein and an immunomodulating agent, can be used for the research of multiple sclerosis. Glatiramer acetate exhibits strong and promiscuous binding to MHC molecules and consequent competition with various myelin antigens for their presentation to T cells. |
| Areas of Interest | Neurological Disease |
| Functions | Virus receptor activity |
| Source# | Synthetic |
Storage | -20°C |
Organism | Human |
InChI | InChI=1S/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2.C2H4O2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6;1-2(3)4/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6);1H3,(H,3,4)/t8-;5-;3-;2-;/m0000./s1 |
InChI Key | FHEAIOHRHQGZPC-KIWGSFCNSA-N |
Isomeric SMILES | C[C@@H](C(=O)O)N.CC(=O)O.C1=CC(=CC=C1C[C@@H](C(=O)O)N)O.C(CCN)C[C@@H](C(=O)O)N.C(CC(=O)O)[C@@H](C(=O)O)N |
BoilingPoint | 385.2ºC at 760mmHg |
Melting Point | N/A |
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