UP_P0C1W8
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| CAT# | X18085 |
| Sequence | CCGVPNAACPPCVCNKTCG |
| Functions | Alpha-A-short conotoxins act on postsynaptic membranes, they selectively bind to the fetal (alpha1/beta1/gamma/delta subunits) mammalian muscle nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks the fetal muscle subtype (IC(50)=66 nM) with 1500/2000-fold greater affinity than the adult (alpha1/beta1/epsilon/delta) subtype (IC(50)=96000 nM). It blocks the currents completely, and dissociates rapidly from the fetal muscle receptor. Has no inhibitory activity on various neuronal nAChRs. This toxin causes a reversible paralysis upon injection into gold fish. |
| Source# | Synthetic |
Long-term Storage Conditions | -20°C |
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