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Somatostatin is a tetradecapeptide which can suppress the growth hormone (GH) secretion and control the pituitary hormone secretion in human CNS.
CAT No: 10-101-32
CAS No: 38916-34-6 (net), 51110-01-1 (acetate)
Synonyms/Alias: SOMATOSTATIN;38916-34-6;Cyclic Somatostatin;Somatostatina;Somatostatine;Somatostatin-14;Somatostatinum;Somatostatin, cyclic;Somatostatin (sheep);Somatostatin 14;Somatostatin acetate;Synthetic somatostatin-14;Somatostatin (rat);Aminopan;Somatostatine [INN-French];Somatostatinum [INN-Latin];Somatostatin (human);Somatostatina [INN-Spanish];Somatostatin (pigeon);CCRIS 3629;Somatostatin [INN:BAN];EINECS 254-186-5;Stilamin;SRIF 14;UNII-6E20216Q0L;MFCD00076762;SOMATOSTATIN [MI];SOMATOSTATIN [INN];SR 9357;SOMATOSTATIN [MART.];Somiaton;SOMATOSTATIN [WHO-DD];CHEBI:64628;SOMATOSTATIN [EP MONOGRAPH];Somatostatin (INN);SRIF;6E20216Q0L;Somatotropin release-inhibiting factor;Somatostatine (INN-French);Somatostatinum (INN-Latin);Somatostatina (INN-Spanish);SOMATOSTATIN (MART.);15-28-Somatostatin-28;CCRIS 7071;SOMATOSTATIN (EP MONOGRAPH);EINECS 256-969-7;Ala-Gly-cyclo-[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys];L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide;L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide;DTXCID6026793;SRIH-14;Ala-Gly-cyclo-(Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys);Somatostatin-1;L-alanyl-N-((4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis((1R)-1-hydroxyethyl)-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl)glycinamide;Somatotropin release inhibiting factor;Recombinant Somatostatin;GH-RIH;Somatostatin-14 Acetate;CHEMBL1823872;SCHEMBL21361053;BDBM81767;H01CB01;AKOS015994634;AC-8931;DB09099;FS27855;HS-2027;NCGC00167137-01;CAS_38916-34-6;CB6417646;C74981;BRD-K14681867-001-01-6;BRD-K14681867-015-01-6;Q22075835;Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH(Cys3-Cys14);ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH,CYS-CYS;ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS 3,14-disulfide;254-186-5;256-969-7;Somatostatin-14 (H-L-Ala-L-Gly-L-Cys(1)-L-Lys-L-Asn-L-Phe-L-Phe-L-Trp-L-Lys-L-Thr-L-Phe-L-Thr-L-Ser-L-Cys(1)-OH);
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M.F/Formula | C76H104N18O19S2 |
M.W/Mr. | 1637.9 |
Sequence | One Letter Code:AGCKNFFWKTFTSC Three Letter Code:H-Ala-Gly-Cys(1)-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys(1)-OH |
Application | Somatostatin acetate is used in the treatment of severe, acute hemorrhages of gastroduodenal ulcers. It is also an experimental anti-diabetic agent. |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
InChI | InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1 |
InChI Key | NHXLMOGPVYXJNR-ATOGVRKGSA-N |
4. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die
5. The spatiotemporal control of signalling and trafficking of the GLP-1R
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