Rotigaptide, also called ZP-123, is a peptide analog, which has been shown to increase gap junction intercellular conductance in cardiac muscle cells. Gap junctions are protein channels that are responsible for conducting electrical impulses between cells in the heart to maintain normal rhythm.
CAT# | 10-101-55 |
CAS | 355151-12-1 |
Background | Rotigaptide (formerly ZP123) is a novel antiarrhythmic peptide that prevents uncoupling of connexin 43 (Cx43)-mediated, gap junction communication during acute metabolic stress. Since rotigaptide's long-term effects on Cx43 are unknown, we studied its effect on Cx43 protein levels at 24 h in neonatal ventricular myocytes. As determined by Western blot analysis, rotigaptide produced a dose-dependent increase in Cx43 protein expression that reached a maximum level at 100 nM. Furthermore, 100 nM rotigaptide markedly increased Cx43 immunoreactivity and Cx43-positive gap junctions as observed in immunocytochemical studies. >> Read More |
Synonyms/Alias | CHEMBL450656; GAP-486; ZP-123; ZP 123; ZP123 peptide; ZP-123 (ZEALAND); acetyl-tyrosyl-prolyl-hydroxyprolyl-glycyl-alanyl-glycinamide; GAP486; GAP 486; Rotigaptide. |
M.F/Formula | C28H39N7O9 |
M.W/Mr. | 617.65 |
Sequence | Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2 |
Labeling Target | Gap junction modulator |
Application | Rotigaptide is currently under clinical investigation for the treatment of cardiac arrhythmias–specifically atrial fibrillation. |
Appearance | Solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Biological Activity | Rotigaptide, also known as GAP-486; ZP-123, is a gap junction modulator potentially for the treatment of ventricular tachycardia and atrial. |
Areas of Interest | Cardiovascular System & Diseases Pituitary & Hypothalamic Hormones |
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