NFAT Inhibitor

NFAT inhibitor is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation f nuclear factor of activated T cells (NFAT). It effectively blocks calcineurin binding to NFAT without disrupting other calcineurin-dependent pathways

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CAT#	R1086
CAS	249537-73-3
Synonyms/Alias	VIVIT peptide
M.F/Formula	C75H118N20O22S
M.W/Mr.	1683.94
Sequence	One Letter Code: MAGPHPVIVITGPHEE Three Letter Code: Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu
Appearance	Lyophilized powder
Purity	>98%
Activity	Inhibitor

CAT#	Product Name	Inquiry
R1509	MCA-SEVNLDAEFR-K(Dnp)-RR, amide	Inquiry
R1313	C-Type Natriuretic Peptide (CNP) (1-22), human	Inquiry
R1073	ICI 154,129	Inquiry
R1232	Bak BH3	Inquiry
R1243	Bombesin	Inquiry

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Storage	-20°C
Solubility	Soluble in water
Shipping Condition	Room Temperature in continental US; may vary elsewhere
InChI	InChI=1S/C75H118N20O22S/c1-12-39(7)59(90-70(111)57(37(3)4)88-68(109)52-19-16-27-95(52)74(115)49(30-44-32-78-36-82-44)87-67(108)51-18-15-26-94(51)53(97)33-79-62(103)41(9)83-63(104)45(76)24-28-118-11)72(113)89-58(38(5)6)71(112)91-60(40(8)13-2)73(114)92-61(42(10)96)69(110)80-34-54(98)93-25-14-17-50(93)66(107)86-48(29-43-31-77-35-81-43)65(106)84-46(20-22-55(99)100)64(105)85-47(75(116)117)21-23-56(101)102/h31-32,35-42,45-52,57-61,96H,12-30,33-34,76H2,1-11H3,(H,77,81)(H,78,82)(H,79,103)(H,80,110)(H,83,104)(H,84,106)(H,85,105)(H,86,107)(H,87,108)(H,88,109)(H,89,113)(H,90,111)(H,91,112)(H,92,114)(H,99,100)(H,101,102)(H,116,117)/t39-,40-,41-,42+,45-,46-,47-,48-,49-,50-,51-,52-,57-,58-,59-,60-,61-/m0/s1
InChI Key	QPMHUXBSHGAVGD-MCDIZDEASA-N
Canonical SMILES	O=C(N(CCC1)[C@@H]1C(N[C@@H](C(C)C)C(N[C@]([C@@H](C)CC)([H])C(N[C@@H](C(C)C)C(N[C@]([C@@H](C)CC)([H])C(N[C@]([C@H](O)C)([H])C(NCC(N(CCC2)[C@@H]2C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CCC(O)=O)=O)=O)CC3=CNC=N3)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC4=CNC
Isomeric SMILES	CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC4=CN=CN4)NC(=O)[C@@H]5CCCN5C(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCSC)N